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- NCIT_C176044 IAO_0000115 "The lactate form of panobinostat, a pan histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon administration, panobinostat selectively targets, binds to and inhibits HDAC, which induces hyperacetylation of core histone proteins. The accumulation of highly acetylated histones leads to chromatin remodeling, an altered pattern of gene expression, inhibition of tumor oncogene transcription and the selective transcription of tumor suppressor genes. This results in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDAC, upregulated in many tumor cell types, is an enzyme family that deacetylates histone proteins." @default.
- NCIT_C176044 NCIT_A7 NCIT_C16682 @default.
- NCIT_C176044 NCIT_NHC0 "C176044" @default.
- NCIT_C176044 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176044 NCIT_P107 "Panobinostat Lactate" @default.
- NCIT_C176044 NCIT_P108 "Panobinostat Lactate" @default.
- NCIT_C176044 NCIT_P208 "CL1413468" @default.
- NCIT_C176044 NCIT_P210 "960055-56-5" @default.
- NCIT_C176044 NCIT_P319 "HN0T99OO4V" @default.
- NCIT_C176044 NCIT_P322 "CTRP" @default.
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- NCIT_C176044 NCIT_P329 "530790" @default.
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- NCIT_C176044 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C176044 referenceCount "2" @default.
- NCIT_C176044 hasExactSynonym "Farydak" @default.
- NCIT_C176044 hasExactSynonym "PANOBINOSTAT LACTATE" @default.
- NCIT_C176044 hasExactSynonym "Panobinostat Lactate Anhydrous" @default.
- NCIT_C176044 hasExactSynonym "Panobinostat Lactate" @default.
- NCIT_C176044 inSubset NCIT_C116977 @default.
- NCIT_C176044 inSubset NCIT_C116978 @default.
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- NCIT_C176044 type Class @default.
- NCIT_C176044 isDefinedBy ncit.owl @default.
- NCIT_C176044 label "Panobinostat Lactate" @default.
- NCIT_C176044 subClassOf B3b94a1fb7dd361681a17c5feebadfa89 @default.
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- NCIT_C176044 subClassOf NCIT_C1946 @default.
- NCIT_C176044 subClassOf NCIT_C274 @default.
- NCIT_C176044 subClassOf NCIT_C471 @default.