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- NCIT_C1762 IAO_0000115 "The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer." @default.
- NCIT_C1762 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1762 NCIT_A6 NCIT_C1518 @default.
- NCIT_C1762 NCIT_A7 NCIT_C38361 @default.
- NCIT_C1762 NCIT_NHC0 "C1762" @default.
- NCIT_C1762 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1762 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1762 NCIT_P107 "Raloxifene Hydrochloride" @default.
- NCIT_C1762 NCIT_P108 "Raloxifene Hydrochloride" @default.
- NCIT_C1762 NCIT_P175 "706725" @default.
- NCIT_C1762 NCIT_P207 "C0618111" @default.
- NCIT_C1762 NCIT_P210 "82640-04-8" @default.
- NCIT_C1762 NCIT_P302 "Breast cancer prevention" @default.
- NCIT_C1762 NCIT_P319 "4F86W47BR6" @default.
- NCIT_C1762 NCIT_P322 "CTRP" @default.
- NCIT_C1762 NCIT_P322 "FDA" @default.
- NCIT_C1762 NCIT_P322 "GDC" @default.
- NCIT_C1762 NCIT_P325 "A drug used to reduce the risk of invasive breast cancer in postmenopausal women who are at high risk of the disease or who have osteoporosis. It is also used to prevent and treat osteoporosis in postmenopausal women. It is also being studied in the prevention of breast cancer in certain premenopausal women and in the prevention and treatment of other conditions. Evista blocks the effects of the hormone estrogen in the breast and increases the amount of calcium in bone. It is a type of selective estrogen receptor modulator (SERM)." @default.
- NCIT_C1762 NCIT_P329 "43109" @default.
- NCIT_C1762 NCIT_P330 "43109" @default.
- NCIT_C1762 NCIT_P350 "C28H27NO4S.HCl" @default.
- NCIT_C1762 NCIT_P366 "Raloxifene_Hydrochloride" @default.
- NCIT_C1762 NCIT_P368 "CHEBI:50740" @default.
- NCIT_C1762 NCIT_P375 "Raloxifene Hydrochloride" @default.
- NCIT_C1762 NCIT_P399 "43109" @default.
- NCIT_C1762 normalizedInformationContent "100" @default.
- NCIT_C1762 referenceCount "1" @default.
- NCIT_C1762 hasExactSynonym "(6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone Hydrochloride" @default.
- NCIT_C1762 hasExactSynonym "Evista" @default.
- NCIT_C1762 hasExactSynonym "Keoxifene Hydrochloride" @default.
- NCIT_C1762 hasExactSynonym "LY-156758" @default.
- NCIT_C1762 hasExactSynonym "Optruma" @default.
- NCIT_C1762 hasExactSynonym "RALOXIFENE HYDROCHLORIDE" @default.
- NCIT_C1762 hasExactSynonym "Raloxifene HCl" @default.
- NCIT_C1762 hasExactSynonym "Raloxifene Hydrochloride" @default.
- NCIT_C1762 hasExactSynonym "Raloxifene hydrochloride" @default.
- NCIT_C1762 hasExactSynonym "Raloxifene.HCl" @default.
- NCIT_C1762 hasExactSynonym "raloxifene hydrochloride" @default.
- NCIT_C1762 inSubset NCIT_C116977 @default.
- NCIT_C1762 inSubset NCIT_C116978 @default.
- NCIT_C1762 inSubset NCIT_C128784 @default.
- NCIT_C1762 inSubset NCIT_C157711 @default.
- NCIT_C1762 inSubset NCIT_C157712 @default.
- NCIT_C1762 inSubset NCIT_C176424 @default.
- NCIT_C1762 inSubset NCIT_C177537 @default.
- NCIT_C1762 inSubset NCIT_C63923 @default.
- NCIT_C1762 type Class @default.
- NCIT_C1762 isDefinedBy ncit.owl @default.
- NCIT_C1762 label "Raloxifene Hydrochloride" @default.
- NCIT_C1762 subClassOf NCIT_C129818 @default.
- NCIT_C1762 subClassOf NCIT_C147908 @default.
- NCIT_C1762 subClassOf NCIT_C163758 @default.
- NCIT_C1762 subClassOf NCIT_C1762 @default.
- NCIT_C1762 subClassOf NCIT_C1821 @default.
- NCIT_C1762 subClassOf NCIT_C1892 @default.
- NCIT_C1762 subClassOf NCIT_C1908 @default.
- NCIT_C1762 subClassOf NCIT_C1909 @default.
- NCIT_C1762 subClassOf NCIT_C274 @default.
- NCIT_C1762 subClassOf NCIT_C481 @default.
- NCIT_C1762 subClassOf NCIT_C483 @default.
- NCIT_C1762 subClassOf NCIT_C547 @default.
- NCIT_C1762 subClassOf NCIT_C548 @default.