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- NCIT_C176509 IAO_0000115 "An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6 inhibitor GLR2007 selectively targets and inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation." @default.
- NCIT_C176509 NCIT_A7 NCIT_C17680 @default.
- NCIT_C176509 NCIT_A7 NCIT_C97386 @default.
- NCIT_C176509 NCIT_NHC0 "C176509" @default.
- NCIT_C176509 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176509 NCIT_P107 "CDK4/6 Inhibitor GLR2007" @default.
- NCIT_C176509 NCIT_P108 "CDK4/6 Inhibitor GLR2007" @default.
- NCIT_C176509 NCIT_P208 "CL1642368" @default.
- NCIT_C176509 NCIT_P322 "CTRP" @default.
- NCIT_C176509 NCIT_P322 "GDC" @default.
- NCIT_C176509 NCIT_P329 "803783" @default.
- NCIT_C176509 NCIT_P330 "803783" @default.
- NCIT_C176509 NCIT_P399 "803783" @default.
- NCIT_C176509 normalizedInformationContent "100" @default.
- NCIT_C176509 referenceCount "1" @default.
- NCIT_C176509 hasExactSynonym "CDK4/6 Inhibitor GLR2007" @default.
- NCIT_C176509 hasExactSynonym "GLR 2007" @default.
- NCIT_C176509 hasExactSynonym "GLR-2007" @default.
- NCIT_C176509 hasExactSynonym "GLR2007" @default.
- NCIT_C176509 inSubset NCIT_C116977 @default.
- NCIT_C176509 inSubset NCIT_C116978 @default.
- NCIT_C176509 inSubset NCIT_C128784 @default.
- NCIT_C176509 inSubset NCIT_C157711 @default.
- NCIT_C176509 inSubset NCIT_C157712 @default.
- NCIT_C176509 inSubset NCIT_C176424 @default.
- NCIT_C176509 type Class @default.
- NCIT_C176509 isDefinedBy ncit.owl @default.
- NCIT_C176509 label "CDK4/6 Inhibitor GLR2007" @default.
- NCIT_C176509 subClassOf NCIT_C129824 @default.
- NCIT_C176509 subClassOf NCIT_C129825 @default.
- NCIT_C176509 subClassOf NCIT_C1404 @default.
- NCIT_C176509 subClassOf NCIT_C163758 @default.
- NCIT_C176509 subClassOf NCIT_C176509 @default.
- NCIT_C176509 subClassOf NCIT_C1908 @default.
- NCIT_C176509 subClassOf NCIT_C1909 @default.
- NCIT_C176509 subClassOf NCIT_C192741 @default.
- NCIT_C176509 subClassOf NCIT_C192742 @default.
- NCIT_C176509 subClassOf NCIT_C2185 @default.
- NCIT_C176509 subClassOf NCIT_C2189 @default.
- NCIT_C176509 subClassOf NCIT_C274 @default.
- NCIT_C176509 subClassOf NCIT_C471 @default.
- NCIT_C176509 subClassOf NCIT_C61074 @default.