Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C176563> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- NCIT_C176563 IAO_0000115 "An orally bioavailable, selective inhibitor of cyclin-dependent kinase 7 (CDK7), with potential antineoplastic activity. Upon oral administration, LY3405105 selectively targets, binds to and inhibits the activity of CDK7, thereby inhibiting CDK7-mediated signaling. Specifically, inhibition of CDK7 prevents phosphorylation of the carboxy-terminal domain (CTD) of RNA Polymerase II, thereby preventing transcription of important cancer-promoting genes. In addition, it prevents phosphorylation of the cell cycle kinases CDK1, 2, 4, and 6, thereby disrupting uncontrolled cell cycle progression. Altogether, this may induce apoptosis, cause cell cycle arrest, inhibit DNA damage repair and inhibit tumor cell proliferation in certain cancers that are dependent on CDK7-mediated transcriptional regulation and signaling. CDK7, a serine/threonine kinase, plays a role in controlling cell cycle progression, transcriptional regulation, and promotes the expression of key oncogenes such as c-Myc and beta-catenin, through the phosphorylation of RNA polymerase II." @default.
- NCIT_C176563 NCIT_A7 NCIT_C17767 @default.
- NCIT_C176563 NCIT_NHC0 "C176563" @default.
- NCIT_C176563 NCIT_P106 "Organic Chemical" @default.
- NCIT_C176563 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176563 NCIT_P107 "CDK7 Inhibitor LY3405105" @default.
- NCIT_C176563 NCIT_P108 "CDK7 Inhibitor LY3405105" @default.
- NCIT_C176563 NCIT_P208 "CL1642442" @default.
- NCIT_C176563 NCIT_P322 "CTRP" @default.
- NCIT_C176563 NCIT_P322 "GDC" @default.
- NCIT_C176563 NCIT_P329 "803785" @default.
- NCIT_C176563 NCIT_P330 "803785" @default.
- NCIT_C176563 NCIT_P399 "803785" @default.
- NCIT_C176563 NCIT_R124 NCIT_C17710 @default.
- NCIT_C176563 NCIT_R124 NCIT_C17828 @default.
- NCIT_C176563 NCIT_R124 NCIT_C28498 @default.
- NCIT_C176563 NCIT_R124 NCIT_C40576 @default.
- NCIT_C176563 NCIT_R124 NCIT_C40577 @default.
- NCIT_C176563 NCIT_R125 NCIT_C16397 @default.
- NCIT_C176563 NCIT_R125 NCIT_C17828 @default.
- NCIT_C176563 NCIT_R125 NCIT_C18824 @default.
- NCIT_C176563 NCIT_R125 NCIT_C20150 @default.
- NCIT_C176563 NCIT_R125 NCIT_C20480 @default.
- NCIT_C176563 NCIT_R125 NCIT_C21102 @default.
- NCIT_C176563 NCIT_R125 NCIT_C40715 @default.
- NCIT_C176563 NCIT_R125 NCIT_C41515 @default.
- NCIT_C176563 NCIT_R125 NCIT_C51037 @default.
- NCIT_C176563 NCIT_R146 NCIT_C16554 @default.
- NCIT_C176563 NCIT_R146 NCIT_C16984 @default.
- NCIT_C176563 NCIT_R146 NCIT_C17018 @default.
- NCIT_C176563 NCIT_R146 NCIT_C17021 @default.
- NCIT_C176563 NCIT_R146 NCIT_C17210 @default.
- NCIT_C176563 NCIT_R146 NCIT_C17325 @default.
- NCIT_C176563 NCIT_R146 NCIT_C17761 @default.
- NCIT_C176563 NCIT_R146 NCIT_C17767 @default.
- NCIT_C176563 NCIT_R146 NCIT_C18466 @default.
- NCIT_C176563 NCIT_R146 NCIT_C20027 @default.
- NCIT_C176563 NCIT_R146 NCIT_C26548 @default.
- NCIT_C176563 normalizedInformationContent "100" @default.
- NCIT_C176563 referenceCount "1" @default.
- NCIT_C176563 hasExactSynonym "CDK7 Inhibitor LY3405105" @default.
- NCIT_C176563 hasExactSynonym "Cyclin-dependent Kinase 7 Inhibitor LY3405105" @default.
- NCIT_C176563 hasExactSynonym "LY 3405105" @default.
- NCIT_C176563 hasExactSynonym "LY-3405105" @default.
- NCIT_C176563 hasExactSynonym "LY3405105" @default.
- NCIT_C176563 inSubset NCIT_C116977 @default.
- NCIT_C176563 inSubset NCIT_C116978 @default.
- NCIT_C176563 inSubset NCIT_C128784 @default.
- NCIT_C176563 inSubset NCIT_C157711 @default.
- NCIT_C176563 inSubset NCIT_C157712 @default.
- NCIT_C176563 inSubset NCIT_C176424 @default.
- NCIT_C176563 type Class @default.
- NCIT_C176563 isDefinedBy ncit.owl @default.
- NCIT_C176563 label "CDK7 Inhibitor LY3405105" @default.
- NCIT_C176563 subClassOf B0152cb92e285559498446da08ba8d86b @default.
- NCIT_C176563 subClassOf B0c09fb32c490286447b01110844064ab @default.
- NCIT_C176563 subClassOf B65f4271df5aa9475f9a3519e8a585171 @default.
- NCIT_C176563 subClassOf B6b75bd29e25691c13aed8325a3df4e82 @default.
- NCIT_C176563 subClassOf B8db990a0f5d0f9a05f670f54b474a664 @default.
- NCIT_C176563 subClassOf B987cc14bf3992e945ade0e2bebd5e970 @default.
- NCIT_C176563 subClassOf Ba0fa961a0be3e3fb2444820556c6688e @default.
- NCIT_C176563 subClassOf Ba66f9606e836705a56183057faba52ec @default.
- NCIT_C176563 subClassOf NCIT_C129824 @default.
- NCIT_C176563 subClassOf NCIT_C129825 @default.
- NCIT_C176563 subClassOf NCIT_C1404 @default.
- NCIT_C176563 subClassOf NCIT_C163758 @default.
- NCIT_C176563 subClassOf NCIT_C176563 @default.
- NCIT_C176563 subClassOf NCIT_C1908 @default.
- NCIT_C176563 subClassOf NCIT_C1909 @default.
- NCIT_C176563 subClassOf NCIT_C2185 @default.
- NCIT_C176563 subClassOf NCIT_C2189 @default.
- NCIT_C176563 subClassOf NCIT_C274 @default.
- NCIT_C176563 subClassOf NCIT_C471 @default.
- NCIT_C176563 subClassOf NCIT_C61074 @default.