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- NCIT_C176627 IAO_0000115 "A radioimmunoconjugate containing h11B6, a humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets human kallikrein-2 (hK2), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225-DOTA-h11B6 JNJ-69086420, the monoclonal antibody moiety of JNJ-69086420 targets and binds to hK2, thereby delivering a cytotoxic dose of alpha radiation to hK2-expressing tumor cells. hK2 is overexpressed on a variety of cancer cells." @default.
- NCIT_C176627 NCIT_A7 NCIT_C18163 @default.
- NCIT_C176627 NCIT_NHC0 "C176627" @default.
- NCIT_C176627 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C176627 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176627 NCIT_P107 "Actinium Ac 225-DOTA-h11B6 JNJ-69086420" @default.
- NCIT_C176627 NCIT_P108 "Actinium Ac 225-DOTA-h11B6 JNJ-69086420" @default.
- NCIT_C176627 NCIT_P208 "CL1642669" @default.
- NCIT_C176627 NCIT_P322 "CTRP" @default.
- NCIT_C176627 NCIT_P322 "GDC" @default.
- NCIT_C176627 NCIT_P329 "803797" @default.
- NCIT_C176627 NCIT_P330 "803797" @default.
- NCIT_C176627 NCIT_P366 "Actinium_Ac_225_Lintuzumab" @default.
- NCIT_C176627 NCIT_P399 "803797" @default.
- NCIT_C176627 normalizedInformationContent "100" @default.
- NCIT_C176627 referenceCount "1" @default.
- NCIT_C176627 hasExactSynonym "225Ac-h11B6 JNJ-69086420" @default.
- NCIT_C176627 hasExactSynonym "Actinium Ac 225-DOTA-h11B6 JNJ-69086420" @default.
- NCIT_C176627 hasExactSynonym "Actinium-225-labeled Anti-kallikrein-2 h11B6 JNJ-69086420" @default.
- NCIT_C176627 hasExactSynonym "Actinium-225-labeled h11B6 JNJ-69086420" @default.
- NCIT_C176627 hasExactSynonym "JNJ 69086420" @default.
- NCIT_C176627 hasExactSynonym "JNJ-69086420" @default.
- NCIT_C176627 hasExactSynonym "JNJ69086420" @default.
- NCIT_C176627 hasExactSynonym "[225Ac]-DOTA-h11B6" @default.
- NCIT_C176627 inSubset NCIT_C116977 @default.
- NCIT_C176627 inSubset NCIT_C116978 @default.
- NCIT_C176627 inSubset NCIT_C128784 @default.
- NCIT_C176627 inSubset NCIT_C157711 @default.
- NCIT_C176627 inSubset NCIT_C157712 @default.
- NCIT_C176627 inSubset NCIT_C176424 @default.
- NCIT_C176627 type Class @default.
- NCIT_C176627 isDefinedBy ncit.owl @default.
- NCIT_C176627 label "Actinium Ac 225-DOTA-h11B6 JNJ-69086420" @default.
- NCIT_C176627 subClassOf NCIT_C129819 @default.
- NCIT_C176627 subClassOf NCIT_C1446 @default.
- NCIT_C176627 subClassOf NCIT_C1511 @default.
- NCIT_C176627 subClassOf NCIT_C1512 @default.
- NCIT_C176627 subClassOf NCIT_C176627 @default.
- NCIT_C176627 subClassOf NCIT_C1908 @default.
- NCIT_C176627 subClassOf NCIT_C1909 @default.
- NCIT_C176627 subClassOf NCIT_C200225 @default.
- NCIT_C176627 subClassOf NCIT_C2124 @default.
- NCIT_C176627 subClassOf NCIT_C274 @default.
- NCIT_C176627 subClassOf NCIT_C307 @default.
- NCIT_C176627 subClassOf NCIT_C308 @default.