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- NCIT_C176747 IAO_0000115 "A cancer vaccine consisting of autologous, monocyte-derived dendritic cells (DCs) that are matured with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) beta, IL-6, prostaglandin E2 (PGE2) and IkB kinase b (IKKb), and loaded by electroporation with autologous total tumor RNA (TTRNA), RNA coding for tumor-associated antigens (TAAs) that may include gp100, tyrosinase, PRAME, MAGE-A3 and/or IDO, and RNA coding for driver mutations that may include GNAQ/GNA11Q209, R183, SF3B1R625, CYSLTR2L129Q and/or PLCB4D630, with potential immunostimulatory and antineoplastic activities. Upon administration, IKKb-matured, RNA-loaded autologous DCs DCIKKb may elicit a highly specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the TAAs and driver mutations encoded by the loaded RNA." @default.
- NCIT_C176747 NCIT_NHC0 "C176747" @default.
- NCIT_C176747 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176747 NCIT_P108 "IKKb-matured RNA-loaded Autologous Dendritic Cells DCIKKb" @default.
- NCIT_C176747 NCIT_P208 "CL1642579" @default.
- NCIT_C176747 NCIT_P322 "GDC" @default.
- NCIT_C176747 NCIT_P329 "803607" @default.
- NCIT_C176747 NCIT_P330 "803607" @default.
- NCIT_C176747 NCIT_P399 "803607" @default.
- NCIT_C176747 normalizedInformationContent "100" @default.
- NCIT_C176747 referenceCount "1" @default.
- NCIT_C176747 hasExactSynonym "DCIKKb" @default.
- NCIT_C176747 hasExactSynonym "IKKb-matured RNA-loaded Autologous DCs DCIKKb" @default.
- NCIT_C176747 hasExactSynonym "IKKb-matured RNA-loaded Autologous Dendritic Cells DCIKKb" @default.
- NCIT_C176747 inSubset NCIT_C128784 @default.
- NCIT_C176747 inSubset NCIT_C157711 @default.
- NCIT_C176747 inSubset NCIT_C157712 @default.
- NCIT_C176747 inSubset NCIT_C176424 @default.
- NCIT_C176747 type Class @default.
- NCIT_C176747 isDefinedBy ncit.owl @default.
- NCIT_C176747 label "IKKb-matured RNA-loaded Autologous Dendritic Cells DCIKKb" @default.
- NCIT_C176747 subClassOf NCIT_C129820 @default.
- NCIT_C176747 subClassOf NCIT_C1663 @default.
- NCIT_C176747 subClassOf NCIT_C176747 @default.
- NCIT_C176747 subClassOf NCIT_C1908 @default.
- NCIT_C176747 subClassOf NCIT_C1909 @default.
- NCIT_C176747 subClassOf NCIT_C274 @default.
- NCIT_C176747 subClassOf NCIT_C28308 @default.
- NCIT_C176747 subClassOf NCIT_C28310 @default.
- NCIT_C176747 subClassOf NCIT_C307 @default.
- NCIT_C176747 subClassOf NCIT_C308 @default.
- NCIT_C176747 subClassOf NCIT_C923 @default.