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NCIT_C17677 IAO_0000115 "Transcription initiation factor TFIID subunit 1 (1872 aa, ~213 kDa) is encoded by the human TAF1 gene. This protein plays a role in protein phosphorylation, cell cycle progression and RNA polymerase II-mediated transcription." @default.
NCIT_C17677 NCIT_NHC0 "C17677" @default.
NCIT_C17677 NCIT_P100 "313650" @default.
NCIT_C17677 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
NCIT_C17677 NCIT_P106 "Enzyme" @default.
NCIT_C17677 NCIT_P107 "Transcription Initiation Factor TFIID Subunit 1" @default.
NCIT_C17677 NCIT_P108 "Transcription Initiation Factor TFIID Subunit 1" @default.
NCIT_C17677 NCIT_P207 "C1146629" @default.
NCIT_C17677 NCIT_P322 "CTRP" @default.
NCIT_C17677 NCIT_P366 "TAF-II-250_Protein" @default.
NCIT_C17677 NCIT_P93 "P21675" @default.
NCIT_C17677 NCIT_P98 "Protein_Has_Biochemical_Function: Ubiquitin-Activating/Conjugating Enzyme" @default.
NCIT_C17677 NCIT_P98 "Protein_Has_Isoforms: Isoforms 1,2" @default.
NCIT_C17677 NCIT_P98 "Protein_Has_Structural_Domain_Or_Motif: Serine/Threonine Kinase Domain" @default.
NCIT_C17677 NCIT_P98 "Protein_Interacts_With: Transcription Start Site, Histone H4, TFIIF Large Subunit, TBP, TAFs, Transcriptional Regulators" @default.
NCIT_C17677 NCIT_P98 "Protein_Plays_Role_In_Biological_Process: G1 Progression, TFIID Assembly" @default.
NCIT_C17677 NCIT_P98 "TAF(II)250, the largest subunit of TFIID, may be phosphorylated by casein kinase II and contains an HMG box and two bromodomains with highly charged helical bundles that bind to diacetylated histone H4 tails. Variant 2 lacks 21 internal amino acids. Similar to Drosophila TAFII-230 and yeast TAFII-111 and TAF145, TAF1 contains N- and C-terminal Ser/Thr kinase domains that auto- and transphosphorylate the basal TFIIF large subunit. TAF1 possesses acetyl transferase activity, acts as an ubiquitin-conjugating enzyme, binds to core promoter transcription start sites, and interacts with TBP, other TAFs, and transcriptional regulators in TFIID assembly and RNA Pol II transcription initiation. Essential for G1 progression, TAF1 links control of transcription to the cell cycle. (from LocusLink, Swiss-Prot, OMIM)" @default.
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