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- NCIT_C176783 IAO_0000115 "An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, saruparib selectively targets and binds to PARP and prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. This may enhance the cytotoxicity of DNA-damaging agents. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. The PARP-mediated repair pathway is dysregulated in a variety of cancer cell types." @default.
- NCIT_C176783 NCIT_A7 NCIT_C48215 @default.
- NCIT_C176783 NCIT_NHC0 "C176783" @default.
- NCIT_C176783 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176783 NCIT_P107 "Saruparib" @default.
- NCIT_C176783 NCIT_P108 "Saruparib" @default.
- NCIT_C176783 NCIT_P208 "CL1642566" @default.
- NCIT_C176783 NCIT_P210 "2589531-76-8" @default.
- NCIT_C176783 NCIT_P319 "16MZ1V3RBT" @default.
- NCIT_C176783 NCIT_P322 "CTRP" @default.
- NCIT_C176783 NCIT_P322 "FDA" @default.
- NCIT_C176783 NCIT_P322 "GDC" @default.
- NCIT_C176783 NCIT_P329 "803799" @default.
- NCIT_C176783 NCIT_P330 "803799" @default.
- NCIT_C176783 NCIT_P399 "803799" @default.
- NCIT_C176783 NCIT_R146 NCIT_C104101 @default.
- NCIT_C176783 NCIT_R146 NCIT_C16554 @default.
- NCIT_C176783 NCIT_R146 NCIT_C17021 @default.
- NCIT_C176783 NCIT_R146 NCIT_C17210 @default.
- NCIT_C176783 NCIT_R146 NCIT_C17434 @default.
- NCIT_C176783 NCIT_R146 NCIT_C20027 @default.
- NCIT_C176783 NCIT_R146 NCIT_C21170 @default.
- NCIT_C176783 NCIT_R146 NCIT_C26548 @default.
- NCIT_C176783 NCIT_R146 NCIT_C48215 @default.
- NCIT_C176783 normalizedInformationContent "100" @default.
- NCIT_C176783 referenceCount "1" @default.
- NCIT_C176783 hasExactSynonym "AZD 5305" @default.
- NCIT_C176783 hasExactSynonym "AZD-5305" @default.
- NCIT_C176783 hasExactSynonym "AZD5305" @default.
- NCIT_C176783 hasExactSynonym "PARP Inhibitor AZD5305" @default.
- NCIT_C176783 hasExactSynonym "SARUPARIB" @default.
- NCIT_C176783 hasExactSynonym "Saruparib" @default.
- NCIT_C176783 inSubset NCIT_C116977 @default.
- NCIT_C176783 inSubset NCIT_C116978 @default.
- NCIT_C176783 inSubset NCIT_C128784 @default.
- NCIT_C176783 inSubset NCIT_C157711 @default.
- NCIT_C176783 inSubset NCIT_C157712 @default.
- NCIT_C176783 inSubset NCIT_C176424 @default.
- NCIT_C176783 inSubset NCIT_C63923 @default.
- NCIT_C176783 type Class @default.
- NCIT_C176783 isDefinedBy ncit.owl @default.
- NCIT_C176783 label "Saruparib" @default.
- NCIT_C176783 subClassOf NCIT_C163758 @default.
- NCIT_C176783 subClassOf NCIT_C176783 @default.
- NCIT_C176783 subClassOf NCIT_C1908 @default.
- NCIT_C176783 subClassOf NCIT_C1909 @default.
- NCIT_C176783 subClassOf NCIT_C274 @default.
- NCIT_C176783 subClassOf NCIT_C471 @default.
- NCIT_C176783 subClassOf NCIT_C62554 @default.