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- NCIT_C176843 IAO_0000115 "An oncolytic viral agent containing the oncolytic, live-attenuated, replication-competent strain of the avian paramyxovirus Newcastle disease virus (NDV) that has been engineered to include a transgene encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), with potential antineoplastic and immunostimulating activities. Upon administration, recombinant NDV-encoding IL-12 MEDI9253 specifically infects and replicates in cancer cells. This may result in a direct cytotoxic effect involving the lysis of tumor cells via apoptotic mechanisms and may eventually lead to an inhibition of cancer cell proliferation. The production and secretion of IL-12 may potentiate and strengthen the anti-tumor immune response and activates the immune system by promoting the activation of natural killer cells (NK cells), inducing secretion of interferon-gamma and promoting cytotoxic T-cell responses against tumor cells." @default.
- NCIT_C176843 NCIT_NHC0 "C176843" @default.
- NCIT_C176843 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176843 NCIT_P106 "Virus" @default.
- NCIT_C176843 NCIT_P107 "Recombinant Newcastle Disease Virus-encoding Interleukin-12 MEDI9253" @default.
- NCIT_C176843 NCIT_P108 "Recombinant Newcastle Disease Virus-encoding Interleukin-12 MEDI9253" @default.
- NCIT_C176843 NCIT_P208 "CL1642600" @default.
- NCIT_C176843 NCIT_P322 "CTRP" @default.
- NCIT_C176843 NCIT_P322 "GDC" @default.
- NCIT_C176843 normalizedInformationContent "100" @default.
- NCIT_C176843 referenceCount "1" @default.
- NCIT_C176843 hasExactSynonym "MEDI 9253" @default.
- NCIT_C176843 hasExactSynonym "MEDI-9253" @default.
- NCIT_C176843 hasExactSynonym "MEDI9253" @default.
- NCIT_C176843 hasExactSynonym "Recombinant NDV-encoding IL-12 MEDI9253" @default.
- NCIT_C176843 hasExactSynonym "Recombinant Newcastle Disease Virus-encoding Interleukin-12 MEDI9253" @default.
- NCIT_C176843 inSubset NCIT_C116977 @default.
- NCIT_C176843 inSubset NCIT_C116978 @default.
- NCIT_C176843 inSubset NCIT_C128784 @default.
- NCIT_C176843 inSubset NCIT_C157711 @default.
- NCIT_C176843 inSubset NCIT_C157712 @default.
- NCIT_C176843 inSubset NCIT_C176424 @default.
- NCIT_C176843 type Class @default.
- NCIT_C176843 isDefinedBy ncit.owl @default.
- NCIT_C176843 label "Recombinant Newcastle Disease Virus-encoding Interleukin-12 MEDI9253" @default.
- NCIT_C176843 subClassOf NCIT_C129821 @default.
- NCIT_C176843 subClassOf NCIT_C176843 @default.
- NCIT_C176843 subClassOf NCIT_C1908 @default.
- NCIT_C176843 subClassOf NCIT_C1909 @default.
- NCIT_C176843 subClassOf NCIT_C274 @default.
- NCIT_C176843 subClassOf NCIT_C307 @default.
- NCIT_C176843 subClassOf NCIT_C717 @default.