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- NCIT_C176850 IAO_0000115 "A preparation of off-the-shelf (OTS) T-lymphocytes, generated from an induced pluripotent stem cell (iPSC) line, that have been genetically modified to express a CD19 1XX chimeric antigen receptor (CAR) that targets the tumor-associated antigen (TAA) CD19, linked to the co-stimulatory intracellular signaling domains of CD28 and the zeta chain of the TCR (T-cell receptor)/CD3 complex (CD3-zeta) (CD28zeta; CD28z), and inserted into the T-cell receptor alpha constant (TRAC) locus and edited for elimination of TCR expression, with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic anti-CD19 1XX-CAR T-cells FT819 specifically recognize and bind to CD19-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. The CD19 1XX CAR T-cells include a 1928zeta mutant, 1XX, which contains one instead of all three immunoreceptor tyrosine-based activation motifs (iTAMs). This may help prevent counterproductive T-cell differentiation and exhaustion, and may enhance the anti-tumor activity of the CAR T-cells. By nullifying the TCR, the possibility of graft versus host disease (GvHD) is eliminated." @default.
- NCIT_C176850 NCIT_A7 NCIT_C38894 @default.
- NCIT_C176850 NCIT_NHC0 "C176850" @default.
- NCIT_C176850 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176850 NCIT_P107 "Allogeneic Anti-CD19 1XX-CAR T-cells FT819" @default.
- NCIT_C176850 NCIT_P108 "Allogeneic Anti-CD19 1XX-CAR T-cells FT819" @default.
- NCIT_C176850 NCIT_P208 "CL1642610" @default.
- NCIT_C176850 NCIT_P322 "CTRP" @default.
- NCIT_C176850 NCIT_P322 "GDC" @default.
- NCIT_C176850 NCIT_P329 "803806" @default.
- NCIT_C176850 NCIT_P330 "803806" @default.
- NCIT_C176850 NCIT_P399 "803806" @default.
- NCIT_C176850 normalizedInformationContent "100" @default.
- NCIT_C176850 referenceCount "1" @default.
- NCIT_C176850 hasExactSynonym "Allogeneic Anti-CD19 1XX-CAR T-cells FT819" @default.
- NCIT_C176850 hasExactSynonym "Allogeneic Anti-CD19 CAR T-cells FT819" @default.
- NCIT_C176850 hasExactSynonym "CAR19-T Cells FT819" @default.
- NCIT_C176850 hasExactSynonym "FT 819" @default.
- NCIT_C176850 hasExactSynonym "FT-819" @default.
- NCIT_C176850 hasExactSynonym "FT819" @default.
- NCIT_C176850 hasExactSynonym "TCR-Less Trac-1XX CAR-T Cells FT819" @default.
- NCIT_C176850 inSubset NCIT_C116977 @default.
- NCIT_C176850 inSubset NCIT_C116978 @default.
- NCIT_C176850 inSubset NCIT_C128784 @default.
- NCIT_C176850 inSubset NCIT_C157711 @default.
- NCIT_C176850 inSubset NCIT_C157712 @default.
- NCIT_C176850 inSubset NCIT_C176424 @default.
- NCIT_C176850 type Class @default.
- NCIT_C176850 isDefinedBy ncit.owl @default.
- NCIT_C176850 label "Allogeneic Anti-CD19 1XX-CAR T-cells FT819" @default.
- NCIT_C176850 subClassOf NCIT_C129820 @default.
- NCIT_C176850 subClassOf NCIT_C129821 @default.
- NCIT_C176850 subClassOf NCIT_C129826 @default.
- NCIT_C176850 subClassOf NCIT_C137999 @default.
- NCIT_C176850 subClassOf NCIT_C142078 @default.
- NCIT_C176850 subClassOf NCIT_C154231 @default.
- NCIT_C176850 subClassOf NCIT_C176018 @default.
- NCIT_C176850 subClassOf NCIT_C176850 @default.
- NCIT_C176850 subClassOf NCIT_C1908 @default.
- NCIT_C176850 subClassOf NCIT_C1909 @default.
- NCIT_C176850 subClassOf NCIT_C1962 @default.
- NCIT_C176850 subClassOf NCIT_C200765 @default.
- NCIT_C176850 subClassOf NCIT_C274 @default.
- NCIT_C176850 subClassOf NCIT_C28676 @default.
- NCIT_C176850 subClassOf NCIT_C307 @default.
- NCIT_C176850 subClassOf NCIT_C308 @default.