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- NCIT_C176871 IAO_0000115 "An agonistic recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, anti-OX40 agonist monoclonal antibody YH-002 selectively targets, binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). This enhances anti-tumor immune responses and prevents Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation." @default.
- NCIT_C176871 NCIT_A7 NCIT_C94790 @default.
- NCIT_C176871 NCIT_NHC0 "C176871" @default.
- NCIT_C176871 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C176871 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C176871 NCIT_P108 "Anti-OX40 Agonist Monoclonal Antibody YH-002" @default.
- NCIT_C176871 NCIT_P208 "CL1642928" @default.
- NCIT_C176871 NCIT_P322 "GDC" @default.
- NCIT_C176871 NCIT_P329 "803647" @default.
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- NCIT_C176871 NCIT_P399 "803647" @default.
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- NCIT_C176871 normalizedInformationContent "100" @default.
- NCIT_C176871 referenceCount "1" @default.
- NCIT_C176871 hasExactSynonym "Agonistic Anti-OX40 Monoclonal Antibody YH-002" @default.
- NCIT_C176871 hasExactSynonym "Anti-OX40 Agonist Monoclonal Antibody YH-002" @default.
- NCIT_C176871 hasExactSynonym "YH 002" @default.
- NCIT_C176871 hasExactSynonym "YH-002" @default.
- NCIT_C176871 hasExactSynonym "YH002" @default.
- NCIT_C176871 inSubset NCIT_C128784 @default.
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- NCIT_C176871 type Class @default.
- NCIT_C176871 isDefinedBy ncit.owl @default.
- NCIT_C176871 label "Anti-OX40 Agonist Monoclonal Antibody YH-002" @default.
- NCIT_C176871 subClassOf B588397eb6b6ae05c3c9dfdd0e0033974 @default.
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- NCIT_C176871 subClassOf NCIT_C96040 @default.