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- NCIT_C176885 IAO_0000115 "A preparation of human allogeneic, 'off-the-shelf' (OTS), non-gene edited T-lymphocytes that are engineered to co-express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and a single short hairpin RNA (shRNA) that disrupts the expression of the CD3zeta component of the T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic shRNA-based anti-BCMA CAR T-cells CYAD-211 recognize and bind to BCMA-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. The downregulation of the expression of the TCR CD3zeta subunit by shRNA prevents the potential induction of graft-versus-host disease (GvHD) by the donor T-cells." @default.
- NCIT_C176885 NCIT_A7 NCIT_C97848 @default.
- NCIT_C176885 NCIT_NHC0 "C176885" @default.
- NCIT_C176885 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176885 NCIT_P107 "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211" @default.
- NCIT_C176885 NCIT_P108 "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211" @default.
- NCIT_C176885 NCIT_P208 "CL1642937" @default.
- NCIT_C176885 NCIT_P322 "CTRP" @default.
- NCIT_C176885 NCIT_P322 "GDC" @default.
- NCIT_C176885 NCIT_P329 "803950" @default.
- NCIT_C176885 NCIT_P330 "803950" @default.
- NCIT_C176885 NCIT_P399 "803950" @default.
- NCIT_C176885 normalizedInformationContent "100" @default.
- NCIT_C176885 referenceCount "1" @default.
- NCIT_C176885 hasExactSynonym "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211" @default.
- NCIT_C176885 hasExactSynonym "Allogeneic shRNA-based Anti-BCMA CAR-T Cells CYAD-211" @default.
- NCIT_C176885 hasExactSynonym "CYAD 211" @default.
- NCIT_C176885 hasExactSynonym "CYAD-211" @default.
- NCIT_C176885 hasExactSynonym "CYAD211" @default.
- NCIT_C176885 inSubset NCIT_C116977 @default.
- NCIT_C176885 inSubset NCIT_C116978 @default.
- NCIT_C176885 inSubset NCIT_C128784 @default.
- NCIT_C176885 inSubset NCIT_C157711 @default.
- NCIT_C176885 inSubset NCIT_C157712 @default.
- NCIT_C176885 inSubset NCIT_C176424 @default.
- NCIT_C176885 type Class @default.
- NCIT_C176885 isDefinedBy ncit.owl @default.
- NCIT_C176885 label "Allogeneic shRNA-based Anti-BCMA CAR T-cells CYAD-211" @default.
- NCIT_C176885 subClassOf NCIT_C129820 @default.
- NCIT_C176885 subClassOf NCIT_C129821 @default.
- NCIT_C176885 subClassOf NCIT_C129826 @default.
- NCIT_C176885 subClassOf NCIT_C137999 @default.
- NCIT_C176885 subClassOf NCIT_C142078 @default.
- NCIT_C176885 subClassOf NCIT_C154231 @default.
- NCIT_C176885 subClassOf NCIT_C176023 @default.
- NCIT_C176885 subClassOf NCIT_C176885 @default.
- NCIT_C176885 subClassOf NCIT_C1908 @default.
- NCIT_C176885 subClassOf NCIT_C1909 @default.
- NCIT_C176885 subClassOf NCIT_C1962 @default.
- NCIT_C176885 subClassOf NCIT_C200765 @default.
- NCIT_C176885 subClassOf NCIT_C274 @default.
- NCIT_C176885 subClassOf NCIT_C28676 @default.
- NCIT_C176885 subClassOf NCIT_C307 @default.
- NCIT_C176885 subClassOf NCIT_C308 @default.