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- NCIT_C176965 IAO_0000115 "A selective inhibitor of the serine/threonine cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF-b; PTEFb), with potential antineoplastic activity. Upon administration, the CDK9 inhibitor GFH009 targets, binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II, leading to the inhibition of gene transcription of various anti-apoptotic proteins. This induces cell cycle arrest and apoptosis and prevents tumor cell proliferation. CDK9 regulates elongation of transcription through phosphorylation of RNA Pol II at serine 2 (p-Ser2-RNAPII). It is upregulated in various tumor cell types and plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival." @default.
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- NCIT_C176965 NCIT_NHC0 "C176965" @default.
- NCIT_C176965 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176965 NCIT_P107 "CDK9 Inhibitor GFH009" @default.
- NCIT_C176965 NCIT_P108 "CDK9 Inhibitor GFH009" @default.
- NCIT_C176965 NCIT_P208 "CL1642764" @default.
- NCIT_C176965 NCIT_P322 "CTRP" @default.
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- NCIT_C176965 NCIT_P329 "804050" @default.
- NCIT_C176965 NCIT_P330 "804050" @default.
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- NCIT_C176965 normalizedInformationContent "100" @default.
- NCIT_C176965 referenceCount "1" @default.
- NCIT_C176965 hasExactSynonym "CDK9 Inhibitor GFH009" @default.
- NCIT_C176965 hasExactSynonym "GFH 009" @default.
- NCIT_C176965 hasExactSynonym "GFH-009" @default.
- NCIT_C176965 hasExactSynonym "GFH009" @default.
- NCIT_C176965 inSubset NCIT_C116977 @default.
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- NCIT_C176965 type Class @default.
- NCIT_C176965 isDefinedBy ncit.owl @default.
- NCIT_C176965 label "CDK9 Inhibitor GFH009" @default.
- NCIT_C176965 subClassOf B026e92001eebfb6647ade56dab284837 @default.
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