Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C176968> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- NCIT_C176968 IAO_0000115 "An orally bioavailable selective inhibitor of wild-type, fusion products and mutated forms of the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, vepafestinib selectively binds to and inhibits the activity of RET. This results in an inhibition of cell growth of tumors cells that exhibit increased RET activity. RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers." @default.
- NCIT_C176968 NCIT_A7 NCIT_C18539 @default.
- NCIT_C176968 NCIT_NHC0 "C176968" @default.
- NCIT_C176968 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C176968 NCIT_P107 "Vepafestinib" @default.
- NCIT_C176968 NCIT_P108 "Vepafestinib" @default.
- NCIT_C176968 NCIT_P208 "CL1642767" @default.
- NCIT_C176968 NCIT_P210 "2129515-96-2" @default.
- NCIT_C176968 NCIT_P319 "LF333FK2V5" @default.
- NCIT_C176968 NCIT_P322 "CTRP" @default.
- NCIT_C176968 NCIT_P322 "FDA" @default.
- NCIT_C176968 NCIT_P322 "GDC" @default.
- NCIT_C176968 NCIT_P329 "804049" @default.
- NCIT_C176968 NCIT_P330 "804049" @default.
- NCIT_C176968 NCIT_P399 "804049" @default.
- NCIT_C176968 normalizedInformationContent "100" @default.
- NCIT_C176968 referenceCount "1" @default.
- NCIT_C176968 hasExactSynonym "RET Inhibitor TAS0953/HM06" @default.
- NCIT_C176968 hasExactSynonym "TAS0953/HM06" @default.
- NCIT_C176968 hasExactSynonym "VEPAFESTINIB" @default.
- NCIT_C176968 hasExactSynonym "Vepafestinib" @default.
- NCIT_C176968 inSubset NCIT_C116977 @default.
- NCIT_C176968 inSubset NCIT_C116978 @default.
- NCIT_C176968 inSubset NCIT_C128784 @default.
- NCIT_C176968 inSubset NCIT_C157711 @default.
- NCIT_C176968 inSubset NCIT_C157712 @default.
- NCIT_C176968 inSubset NCIT_C176424 @default.
- NCIT_C176968 inSubset NCIT_C63923 @default.
- NCIT_C176968 type Class @default.
- NCIT_C176968 isDefinedBy ncit.owl @default.
- NCIT_C176968 label "Vepafestinib" @default.
- NCIT_C176968 subClassOf NCIT_C129824 @default.
- NCIT_C176968 subClassOf NCIT_C129825 @default.
- NCIT_C176968 subClassOf NCIT_C1404 @default.
- NCIT_C176968 subClassOf NCIT_C159438 @default.
- NCIT_C176968 subClassOf NCIT_C163758 @default.
- NCIT_C176968 subClassOf NCIT_C176968 @default.
- NCIT_C176968 subClassOf NCIT_C1908 @default.
- NCIT_C176968 subClassOf NCIT_C1909 @default.
- NCIT_C176968 subClassOf NCIT_C1967 @default.
- NCIT_C176968 subClassOf NCIT_C2189 @default.
- NCIT_C176968 subClassOf NCIT_C274 @default.
- NCIT_C176968 subClassOf NCIT_C471 @default.