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- NCIT_C177152 IAO_0000115 "A preparation of allogeneic, off-the-shelf natural killer (NK) cells, derived from umbilical cord blood (UCB) and ex vivo-expanded, that expresses a high-affinity variant of CD16, with potential immunostimulatory and antineoplastic activities. Upon administration, UCB-derived CD16-expressing NK cells AB-101 lyse tumor cells. NK cells AB-101 also secrete pro-inflammatory cytokines, which further stimulate an anti-tumor immune response. Upon coadministration with tumor-targeting monoclonal antibodies, the Fab moiety of the antibodies bind to the tumor-associated antigens (TAAs) expressed on tumor cells and the Fc moiety of the antibodies bind to CD16 expressed on NK cells AB-101. This leads to NK cell activation, cytokine secretion and antibody-dependent cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune response." @default.
- NCIT_C177152 NCIT_NHC0 "C177152" @default.
- NCIT_C177152 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C177152 NCIT_P107 "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101" @default.
- NCIT_C177152 NCIT_P108 "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101" @default.
- NCIT_C177152 NCIT_P208 "CL1643101" @default.
- NCIT_C177152 NCIT_P322 "CTRP" @default.
- NCIT_C177152 NCIT_P322 "GDC" @default.
- NCIT_C177152 NCIT_P329 "804183" @default.
- NCIT_C177152 NCIT_P330 "804183" @default.
- NCIT_C177152 NCIT_P399 "804183" @default.
- NCIT_C177152 normalizedInformationContent "100" @default.
- NCIT_C177152 referenceCount "1" @default.
- NCIT_C177152 hasExactSynonym "AB 101" @default.
- NCIT_C177152 hasExactSynonym "AB-101" @default.
- NCIT_C177152 hasExactSynonym "AB101" @default.
- NCIT_C177152 hasExactSynonym "NK Cells AB-101" @default.
- NCIT_C177152 hasExactSynonym "UCB-derived CD16-expressing NK Cells AB-101" @default.
- NCIT_C177152 hasExactSynonym "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101" @default.
- NCIT_C177152 inSubset NCIT_C116977 @default.
- NCIT_C177152 inSubset NCIT_C116978 @default.
- NCIT_C177152 inSubset NCIT_C128784 @default.
- NCIT_C177152 inSubset NCIT_C157711 @default.
- NCIT_C177152 inSubset NCIT_C157712 @default.
- NCIT_C177152 inSubset NCIT_C176424 @default.
- NCIT_C177152 type Class @default.
- NCIT_C177152 isDefinedBy ncit.owl @default.
- NCIT_C177152 label "Umbilical Cord Blood-derived CD16-expressing Natural Killer Cells AB-101" @default.
- NCIT_C177152 subClassOf NCIT_C129820 @default.
- NCIT_C177152 subClassOf NCIT_C129821 @default.
- NCIT_C177152 subClassOf NCIT_C129826 @default.
- NCIT_C177152 subClassOf NCIT_C142078 @default.
- NCIT_C177152 subClassOf NCIT_C177152 @default.
- NCIT_C177152 subClassOf NCIT_C1908 @default.
- NCIT_C177152 subClassOf NCIT_C1909 @default.
- NCIT_C177152 subClassOf NCIT_C201545 @default.
- NCIT_C177152 subClassOf NCIT_C274 @default.
- NCIT_C177152 subClassOf NCIT_C28676 @default.
- NCIT_C177152 subClassOf NCIT_C307 @default.
- NCIT_C177152 subClassOf NCIT_C308 @default.