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- NCIT_C177247 IAO_0000115 "A mutated neoantigen peptide consisting of amino acids 585 through 614 of the v-raf murine sarcoma viral oncogene homolog B1 (BRAF; B-raf) and containing the specific mutation V600E, and to which a histidine has been added to the N-terminus, with potential immunostimulating and antineoplastic activities. Upon administration, the BRAF585-614 (V600E) peptide may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing the mutated BRAF V600E. BRAF, a serine/threonine protein kinase, plays a key role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations, including the BRAF(V600E) mutation, in which valine (V) is substituted by glutamic acid (E) at amino acid 600." @default.
- NCIT_C177247 NCIT_NHC0 "C177247" @default.
- NCIT_C177247 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C177247 NCIT_P107 "BRAF585-614 (V600E) Peptide" @default.
- NCIT_C177247 NCIT_P108 "BRAF585-614 (V600E) Peptide" @default.
- NCIT_C177247 NCIT_P208 "CL1643070" @default.
- NCIT_C177247 NCIT_P322 "CTRP" @default.
- NCIT_C177247 NCIT_P322 "GDC" @default.
- NCIT_C177247 NCIT_P329 "804181" @default.
- NCIT_C177247 NCIT_P330 "804181" @default.
- NCIT_C177247 NCIT_P399 "804181" @default.
- NCIT_C177247 normalizedInformationContent "100" @default.
- NCIT_C177247 referenceCount "1" @default.
- NCIT_C177247 hasExactSynonym "BRAF 585-614 (V600E) Peptide" @default.
- NCIT_C177247 hasExactSynonym "BRAF(V600E)585-614 Peptide" @default.
- NCIT_C177247 hasExactSynonym "BRAF585-614 (V600E) Peptide" @default.
- NCIT_C177247 hasExactSynonym "NeoAg-mBRAF Peptide" @default.
- NCIT_C177247 hasExactSynonym "Neoantigen-mBRAF Peptide" @default.
- NCIT_C177247 inSubset NCIT_C116977 @default.
- NCIT_C177247 inSubset NCIT_C116978 @default.
- NCIT_C177247 inSubset NCIT_C128784 @default.
- NCIT_C177247 inSubset NCIT_C157711 @default.
- NCIT_C177247 inSubset NCIT_C157712 @default.
- NCIT_C177247 inSubset NCIT_C176424 @default.
- NCIT_C177247 type Class @default.
- NCIT_C177247 isDefinedBy ncit.owl @default.
- NCIT_C177247 label "BRAF585-614 (V600E) Peptide" @default.
- NCIT_C177247 subClassOf NCIT_C129820 @default.
- NCIT_C177247 subClassOf NCIT_C1663 @default.
- NCIT_C177247 subClassOf NCIT_C177247 @default.
- NCIT_C177247 subClassOf NCIT_C1908 @default.
- NCIT_C177247 subClassOf NCIT_C1909 @default.
- NCIT_C177247 subClassOf NCIT_C2517 @default.
- NCIT_C177247 subClassOf NCIT_C274 @default.
- NCIT_C177247 subClassOf NCIT_C307 @default.
- NCIT_C177247 subClassOf NCIT_C308 @default.
- NCIT_C177247 subClassOf NCIT_C923 @default.