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- NCIT_C177282 IAO_0000115 "An off-the-shelf (OTS) cancer vaccine containing a live-attenuated strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding a fusion protein composed of specific prostate cancer (PC) neoantigens fused to a fragment of the immunostimulant listeriolysin O (LLO) protein, with potential immunostimulatory and antineoplastic activities. Upon administration of the Lm-LLO-PC neoantigens vaccine ADXS-504, the expressed LLO-PC neoantigens is processed by antigen presenting cells (APCs), presented to the immune system by both major histocompatibility complex (MHC) I and II molecules, and activates the immune system to exert both an innate and adaptive immune response involving the recruitment and activation of T-lymphocytes against neoantigen-expressing prostate cancer cells as well as the inhibition of tumor-infiltrating T regulatory cells (T regs) and myeloid-derived suppressor cells (MDSCs). This further modulates the tumor microenvironment (TME) and further results in tumor cell eradication. The neoantigens in ADXS-504 are composed of public hotspot mutations and proprietary tumor associated antigen (TAAs)." @default.
- NCIT_C177282 NCIT_NHC0 "C177282" @default.
- NCIT_C177282 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C177282 NCIT_P107 "Listeria monocytogenes-LLO-Prostate Cancer Neoantigens Vaccine ADXS-504" @default.
- NCIT_C177282 NCIT_P108 "Listeria monocytogenes-LLO-Prostate Cancer Neoantigens Vaccine ADXS-504" @default.
- NCIT_C177282 NCIT_P208 "CL1643049" @default.
- NCIT_C177282 NCIT_P322 "CTRP" @default.
- NCIT_C177282 NCIT_P322 "GDC" @default.
- NCIT_C177282 NCIT_P329 "804613" @default.
- NCIT_C177282 NCIT_P330 "804613" @default.
- NCIT_C177282 NCIT_P399 "804613" @default.
- NCIT_C177282 normalizedInformationContent "100" @default.
- NCIT_C177282 referenceCount "1" @default.
- NCIT_C177282 hasExactSynonym "ADXS 504" @default.
- NCIT_C177282 hasExactSynonym "ADXS-504" @default.
- NCIT_C177282 hasExactSynonym "ADXS504" @default.
- NCIT_C177282 hasExactSynonym "Listeria monocytogenes-LLO-PC Neoantigens Vaccine ADXS-504" @default.
- NCIT_C177282 hasExactSynonym "Listeria monocytogenes-LLO-Prostate Cancer Neoantigens Vaccine ADXS-504" @default.
- NCIT_C177282 hasExactSynonym "Lm-LLO-PC Neoantigens Vaccine ADXS-504" @default.
- NCIT_C177282 hasExactSynonym "Lm-LLO-Prostate Cancer Neoantigens ADXS-504" @default.
- NCIT_C177282 inSubset NCIT_C116977 @default.
- NCIT_C177282 inSubset NCIT_C116978 @default.
- NCIT_C177282 inSubset NCIT_C128784 @default.
- NCIT_C177282 inSubset NCIT_C157711 @default.
- NCIT_C177282 inSubset NCIT_C157712 @default.
- NCIT_C177282 inSubset NCIT_C176424 @default.
- NCIT_C177282 type Class @default.
- NCIT_C177282 isDefinedBy ncit.owl @default.
- NCIT_C177282 label "Listeria monocytogenes-LLO-Prostate Cancer Neoantigens Vaccine ADXS-504" @default.
- NCIT_C177282 subClassOf NCIT_C129820 @default.
- NCIT_C177282 subClassOf NCIT_C1663 @default.
- NCIT_C177282 subClassOf NCIT_C177282 @default.
- NCIT_C177282 subClassOf NCIT_C1908 @default.
- NCIT_C177282 subClassOf NCIT_C1909 @default.
- NCIT_C177282 subClassOf NCIT_C274 @default.
- NCIT_C177282 subClassOf NCIT_C307 @default.
- NCIT_C177282 subClassOf NCIT_C308 @default.
- NCIT_C177282 subClassOf NCIT_C39619 @default.
- NCIT_C177282 subClassOf NCIT_C923 @default.