Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C177533> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- NCIT_C177533 IAO_0000115 "A preparation of allogeneic natural killer T-lymphocytes (NKTs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, interleukin 15 (IL-15) and the costimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD19-CAR-CD28-IL-15-expressing NKTs target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. CD28 costimulatory molecule enhances activation and signaling after recognition of CD19, and may increase proliferation of T-cells and antitumor activity. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies." @default.
- NCIT_C177533 NCIT_A7 NCIT_C38894 @default.
- NCIT_C177533 NCIT_NHC0 "C177533" @default.
- NCIT_C177533 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C177533 NCIT_P107 "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells" @default.
- NCIT_C177533 NCIT_P108 "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells" @default.
- NCIT_C177533 NCIT_P208 "CL1643232" @default.
- NCIT_C177533 NCIT_P322 "CTRP" @default.
- NCIT_C177533 NCIT_P322 "GDC" @default.
- NCIT_C177533 NCIT_P329 "804626" @default.
- NCIT_C177533 NCIT_P330 "804626" @default.
- NCIT_C177533 NCIT_P399 "804626" @default.
- NCIT_C177533 normalizedInformationContent "100" @default.
- NCIT_C177533 referenceCount "1" @default.
- NCIT_C177533 hasExactSynonym "Allogeneic Anti-CD19 CAR/IL-15-expressing Natural Killer T-cells" @default.
- NCIT_C177533 hasExactSynonym "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing NKTs" @default.
- NCIT_C177533 hasExactSynonym "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells" @default.
- NCIT_C177533 hasExactSynonym "Allogeneic Anti-CD19-CAR-IL-15-expressing Natural Killer T-cells" @default.
- NCIT_C177533 hasExactSynonym "CD19.CAR Allogeneic NKT Cells" @default.
- NCIT_C177533 hasExactSynonym "CD19.CAR-aNKT Cells" @default.
- NCIT_C177533 hasExactSynonym "CD19.CAR-aNKTs" @default.
- NCIT_C177533 inSubset NCIT_C116977 @default.
- NCIT_C177533 inSubset NCIT_C116978 @default.
- NCIT_C177533 inSubset NCIT_C128784 @default.
- NCIT_C177533 inSubset NCIT_C157711 @default.
- NCIT_C177533 inSubset NCIT_C157712 @default.
- NCIT_C177533 inSubset NCIT_C176424 @default.
- NCIT_C177533 type Class @default.
- NCIT_C177533 isDefinedBy ncit.owl @default.
- NCIT_C177533 label "Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells" @default.
- NCIT_C177533 subClassOf NCIT_C129820 @default.
- NCIT_C177533 subClassOf NCIT_C129821 @default.
- NCIT_C177533 subClassOf NCIT_C129826 @default.
- NCIT_C177533 subClassOf NCIT_C137999 @default.
- NCIT_C177533 subClassOf NCIT_C142078 @default.
- NCIT_C177533 subClassOf NCIT_C154231 @default.
- NCIT_C177533 subClassOf NCIT_C176018 @default.
- NCIT_C177533 subClassOf NCIT_C177533 @default.
- NCIT_C177533 subClassOf NCIT_C1908 @default.
- NCIT_C177533 subClassOf NCIT_C1909 @default.
- NCIT_C177533 subClassOf NCIT_C1962 @default.
- NCIT_C177533 subClassOf NCIT_C200765 @default.
- NCIT_C177533 subClassOf NCIT_C274 @default.
- NCIT_C177533 subClassOf NCIT_C28676 @default.
- NCIT_C177533 subClassOf NCIT_C307 @default.
- NCIT_C177533 subClassOf NCIT_C308 @default.