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- NCIT_C177739 IAO_0000115 "A peptide cancer vaccine composed of a long peptide, containing amino acids 19 through 27 (FMTYWHLLNAFTVTVPKDL), obtained from the tumor-associated antigen (TAA) and immune checkpoint molecule programmed cell death-1 ligand 1 (PD-L1), with potential immunomodulating and antineoplastic activities. Upon vaccination with long PD-L1 peptide vaccine, the peptide may activate the immune system to induce an immune response against PD-L1-expressing cells. This may induce a cytotoxic T-lymphocytes (CTLs)-mediated immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed on many human cancer cell types as well as on antigen presenting cells (APCs) and immunosuppressive cells in the tumor micro-environment (TME), such as regulatory T-cells (Tregs). PD-L1 binding to its cognate receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) on T-cells suppresses the immune system and results in increased immune evasion and decreased CTL activation." @default.
- NCIT_C177739 NCIT_NHC0 "C177739" @default.
- NCIT_C177739 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C177739 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C177739 NCIT_P108 "Long PD-L1 Peptide Vaccine" @default.
- NCIT_C177739 NCIT_P208 "CL1647567" @default.
- NCIT_C177739 NCIT_P322 "GDC" @default.
- NCIT_C177739 NCIT_P329 "803980" @default.
- NCIT_C177739 NCIT_P330 "803980" @default.
- NCIT_C177739 NCIT_P399 "803980" @default.
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- NCIT_C177739 normalizedInformationContent "100" @default.
- NCIT_C177739 referenceCount "1" @default.
- NCIT_C177739 hasExactSynonym "Long PD-L1 Peptide Vaccine" @default.
- NCIT_C177739 hasExactSynonym "PD-L1 Long Peptide Vaccine" @default.
- NCIT_C177739 hasExactSynonym "PD-L1 Long Vaccine" @default.
- NCIT_C177739 hasExactSynonym "PD-L1 Long(19-27) Peptide Vaccine" @default.
- NCIT_C177739 inSubset NCIT_C128784 @default.
- NCIT_C177739 inSubset NCIT_C157711 @default.
- NCIT_C177739 inSubset NCIT_C157712 @default.
- NCIT_C177739 inSubset NCIT_C176424 @default.
- NCIT_C177739 type Class @default.
- NCIT_C177739 isDefinedBy ncit.owl @default.
- NCIT_C177739 label "Long PD-L1 Peptide Vaccine" @default.
- NCIT_C177739 subClassOf B11c54e7c910f1f26104eceeb3509065d @default.
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- NCIT_C177739 subClassOf NCIT_C274 @default.
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- NCIT_C177739 subClassOf NCIT_C923 @default.