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- NCIT_C177741 IAO_0000115 "A recombinant T-cell activating bispecific antibody directed against the B-cell-specific membrane protein CD19 and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, CD3-activating CD19 bi-specific antibody A-319 targets and binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD19 antigen expressed on malignant B-cells. This activates and redirects CTLs, bringing CD19-expressing tumor cells and CTLs together, and results in a CTL-mediated immune response against CD19-expressing tumor cells. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages." @default.
- NCIT_C177741 NCIT_NHC0 "C177741" @default.
- NCIT_C177741 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C177741 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C177741 NCIT_P108 "CD3-activating CD19 Bi-specific Antibody A-319" @default.
- NCIT_C177741 NCIT_P208 "CL1647591" @default.
- NCIT_C177741 NCIT_P322 "GDC" @default.
- NCIT_C177741 NCIT_P329 "803989" @default.
- NCIT_C177741 NCIT_P330 "803989" @default.
- NCIT_C177741 NCIT_P399 "803989" @default.
- NCIT_C177741 NCIT_R124 NCIT_C17710 @default.
- NCIT_C177741 NCIT_R124 NCIT_C17828 @default.
- NCIT_C177741 NCIT_R124 NCIT_C18219 @default.
- NCIT_C177741 NCIT_R124 NCIT_C19986 @default.
- NCIT_C177741 NCIT_R124 NCIT_C40474 @default.
- NCIT_C177741 normalizedInformationContent "100" @default.
- NCIT_C177741 referenceCount "1" @default.
- NCIT_C177741 hasExactSynonym "A 319" @default.
- NCIT_C177741 hasExactSynonym "A-319" @default.
- NCIT_C177741 hasExactSynonym "A319" @default.
- NCIT_C177741 hasExactSynonym "CD3-activating CD19 Bi-specific Antibody A-319" @default.
- NCIT_C177741 hasExactSynonym "Recombinant Anti-CD19/CD3 Antibody A-319" @default.
- NCIT_C177741 inSubset NCIT_C128784 @default.
- NCIT_C177741 inSubset NCIT_C157711 @default.
- NCIT_C177741 inSubset NCIT_C157712 @default.
- NCIT_C177741 inSubset NCIT_C176424 @default.
- NCIT_C177741 type Class @default.
- NCIT_C177741 isDefinedBy ncit.owl @default.
- NCIT_C177741 label "CD3-activating CD19 Bi-specific Antibody A-319" @default.
- NCIT_C177741 subClassOf NCIT_C112883 @default.
- NCIT_C177741 subClassOf NCIT_C112889 @default.
- NCIT_C177741 subClassOf NCIT_C129820 @default.
- NCIT_C177741 subClassOf NCIT_C129821 @default.
- NCIT_C177741 subClassOf NCIT_C129822 @default.
- NCIT_C177741 subClassOf NCIT_C1454 @default.
- NCIT_C177741 subClassOf NCIT_C163758 @default.
- NCIT_C177741 subClassOf NCIT_C177741 @default.
- NCIT_C177741 subClassOf NCIT_C1908 @default.
- NCIT_C177741 subClassOf NCIT_C1909 @default.
- NCIT_C177741 subClassOf NCIT_C198634 @default.
- NCIT_C177741 subClassOf NCIT_C201282 @default.
- NCIT_C177741 subClassOf NCIT_C20401 @default.
- NCIT_C177741 subClassOf NCIT_C274 @default.
- NCIT_C177741 subClassOf NCIT_C28227 @default.
- NCIT_C177741 subClassOf NCIT_C307 @default.
- NCIT_C177741 subClassOf NCIT_C308 @default.