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- NCIT_C17775 IAO_0000115 "Human telomeric-repeat binding factor proteins (TRF) 1 and 2 are involved in the control of telomere dynamics in vivo. Reduced expression of TRF1 and TRF2 mRNAs was observed in human malignant hematopoietic and acute leukemia cell lines. However, expression of TRF1 and TRF2 mRNAs increased during differentiation of malignant hematopoietic cell line when induced artificially. Furthermore, studies from gastrointestinal carcinogenesis suggested that down-regulation of the TRF1 expression in tumor cells may be involved in cell immortalization. Together with hTERT, TRF1 and TRF2 are important regulators of telomerase activity and represent potential targets for cancer therapy." @default.
- NCIT_C17775 NCIT_NHC0 "C17775" @default.
- NCIT_C17775 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C17775 NCIT_P108 "Telomeric-Repeat Binding Factor" @default.
- NCIT_C17775 NCIT_P207 "C1336701" @default.
- NCIT_C17775 NCIT_P366 "Telomeric-Repeat_Binding_Factor" @default.
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- NCIT_C17775 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C17775 referenceCount "4" @default.
- NCIT_C17775 hasExactSynonym "TRF Protein" @default.
- NCIT_C17775 hasExactSynonym "Telomeric-Repeat Binding Factor" @default.
- NCIT_C17775 type Class @default.
- NCIT_C17775 isDefinedBy ncit.owl @default.
- NCIT_C17775 label "Telomeric-Repeat Binding Factor" @default.
- NCIT_C17775 subClassOf B601bc06397eec4f290468787a8b50f71 @default.
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- NCIT_C17775 subClassOf NCIT_C16518 @default.
- NCIT_C17775 subClassOf NCIT_C17021 @default.
- NCIT_C17775 subClassOf NCIT_C17728 @default.
- NCIT_C17775 subClassOf NCIT_C17775 @default.
- NCIT_C17775 subClassOf NCIT_C20027 @default.
- NCIT_C17775 subClassOf NCIT_C26548 @default.