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- NCIT_C17777 IAO_0000115 "BCL6 protein is may be a transcription factor and contains six zinc finger motifs and shares an N-terminal POZ domain homologous to other transcription factors. BCL6 protein is predominantly expressed in the B-cell lineage and found in mature B cells. BCL6 is expressed in germinal centers, including all centroblasts and centrocytes. BCL6 is present in DNA-binding complexes and can repress transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. Target genes have roles in B-cell activation (CD69, CD44, EBI2, ID2, LEU13, and STAT1), B-cell differentiation (BLIMP1, CD10, AMYB, BCL7A, CD19, and CD20), inflammation (MIP1A, IP10, and CXCR4), and cell cycle control (p27(KIP1) and cyclin D2). Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. (from OMIM 109565 and NCI)" @default.
- NCIT_C17777 NCIT_NHC0 "C17777" @default.
- NCIT_C17777 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C17777 NCIT_P108 "BCL6 Protein" @default.
- NCIT_C17777 NCIT_P200 "Transcription Corepressor" @default.
- NCIT_C17777 NCIT_P203 "Protein_Kind" @default.
- NCIT_C17777 NCIT_P204 "Protein_Plays_Role_In_Biological_Process|Metal Ion Binding" @default.
- NCIT_C17777 NCIT_P310 "Retired_Concept" @default.
- NCIT_C17777 NCIT_P98 "Use 'B-Cell Lymphoma 6 Protein'" @default.
- NCIT_C17777 normalizedInformationContent "100" @default.
- NCIT_C17777 referenceCount "1" @default.
- NCIT_C17777 hasExactSynonym "B-Cell Lymphoma 6 Protein" @default.
- NCIT_C17777 hasExactSynonym "BCL6 Protein" @default.
- NCIT_C17777 hasExactSynonym "LAZ3" @default.
- NCIT_C17777 hasExactSynonym "Lymphoma-Associated Zinc Finger Gene on Chromosome 3" @default.
- NCIT_C17777 hasExactSynonym "ZNF51" @default.
- NCIT_C17777 hasExactSynonym "Zinc Finger Protein 51" @default.
- NCIT_C17777 type Class @default.
- NCIT_C17777 isDefinedBy ncit.owl @default.
- NCIT_C17777 label "BCL6 Protein" @default.
- NCIT_C17777 subClassOf NCIT_C17777 @default.
- NCIT_C17777 subClassOf NCIT_C28428 @default.
- NCIT_C17777 subClassOf NCIT_C83479 @default.
- NCIT_C17777 deprecated "true" @default.