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- NCIT_C178139 IAO_0000115 "A vaccine composed of a molecular clamp stabilized form of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein (SP) combined with a squalene-based vaccine adjuvant, MF59, with potential immunomodulating and anti-COVID-19 activities. Upon administration of MF59 adjuvanted molecular clamp stabilized SARS-CoV-2 SP vaccine, the SARS-CoV-2 SP activates the immune system to produce anti-SARS-CoV-2 SP antibodies and T-cell responses against SARS-CoV-2 SP. The antibodies recognize the SP and kill SARS-CoV-2. This prevents SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. The molecular clamp holds the SARS-CoV-2 SP in the otherwise unstable prefusion position, which may generate a more robust antibody response. The adjuvant strongly stimulates both T-cell and antibody immune responses when combined with the molecular clamp stabilized SARS-CoV-2 SP." @default.
- NCIT_C178139 NCIT_NHC0 "C178139" @default.
- NCIT_C178139 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178139 NCIT_P108 "MF59 Adjuvanted Molecular Clamp Stabilized SARS-CoV-2 Spike Protein Vaccine" @default.
- NCIT_C178139 NCIT_P208 "CL1647676" @default.
- NCIT_C178139 NCIT_R124 NCIT_C17828 @default.
- NCIT_C178139 NCIT_R124 NCIT_C17930 @default.
- NCIT_C178139 NCIT_R124 NCIT_C17937 @default.
- NCIT_C178139 NCIT_R124 NCIT_C18839 @default.
- NCIT_C178139 NCIT_R124 NCIT_C21124 @default.
- NCIT_C178139 NCIT_R124 NCIT_C45548 @default.
- NCIT_C178139 normalizedInformationContent "100" @default.
- NCIT_C178139 referenceCount "1" @default.
- NCIT_C178139 hasExactSynonym "MF59 Adjuvanted Molecular Clamp Stabilized SARS-CoV-2 SP Vaccine" @default.
- NCIT_C178139 hasExactSynonym "MF59 Adjuvanted Molecular Clamp Stabilized SARS-CoV-2 Spike Protein Vaccine" @default.
- NCIT_C178139 hasExactSynonym "MF59 Adjuvanted SARS-CoV-2 Sclamp Vaccine" @default.
- NCIT_C178139 inSubset NCIT_C173381 @default.
- NCIT_C178139 inSubset NCIT_C173383 @default.
- NCIT_C178139 type Class @default.
- NCIT_C178139 isDefinedBy ncit.owl @default.
- NCIT_C178139 label "MF59 Adjuvanted Molecular Clamp Stabilized SARS-CoV-2 Spike Protein Vaccine" @default.
- NCIT_C178139 subClassOf NCIT_C173023 @default.
- NCIT_C178139 subClassOf NCIT_C1752 @default.
- NCIT_C178139 subClassOf NCIT_C178139 @default.
- NCIT_C178139 subClassOf NCIT_C1908 @default.
- NCIT_C178139 subClassOf NCIT_C1909 @default.
- NCIT_C178139 subClassOf NCIT_C307 @default.
- NCIT_C178139 subClassOf NCIT_C308 @default.
- NCIT_C178139 subClassOf NCIT_C923 @default.