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- NCIT_C178219 IAO_0000115 "A recombinant protein consisting of an antigen-binding fragment (Fab) of CSR02, a monoclonal antibody directed against plasmalemma vesicle associated protein (PLVAP), and linked to human tissue factor (TF), with potential antineoplastic activity. Upon intra-arterial (IA) infusion of CSR02-Fab-TF, the Fab moiety targets and binds to the vascular endothelial cell specific protein PLVAP that is present on the blood vessels of hepatocellular carcinoma (HCC) but that is not present on the blood vessels of normal liver tissue. In turn, TF initiates the clotting cascade, thereby blocking blood supply from the hepatic artery to the HCC. This deprives the HCC of its blood supply and leads to tumor cell death." @default.
- NCIT_C178219 NCIT_NHC0 "C178219" @default.
- NCIT_C178219 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178219 NCIT_P107 "Anti-PLVAP CSR02-Fab-Tissue Factor" @default.
- NCIT_C178219 NCIT_P108 "Anti-PLVAP CSR02-Fab-Tissue Factor" @default.
- NCIT_C178219 NCIT_P208 "CL1647881" @default.
- NCIT_C178219 NCIT_P322 "CTRP" @default.
- NCIT_C178219 NCIT_P399 "810746" @default.
- NCIT_C178219 normalizedInformationContent "100" @default.
- NCIT_C178219 referenceCount "1" @default.
- NCIT_C178219 hasExactSynonym "Anti-PLVAP CSR02-Fab-Tissue Factor" @default.
- NCIT_C178219 hasExactSynonym "CSR02-Fab-TF" @default.
- NCIT_C178219 inSubset NCIT_C116977 @default.
- NCIT_C178219 inSubset NCIT_C116978 @default.
- NCIT_C178219 inSubset NCIT_C128784 @default.
- NCIT_C178219 inSubset NCIT_C176424 @default.
- NCIT_C178219 type Class @default.
- NCIT_C178219 isDefinedBy ncit.owl @default.
- NCIT_C178219 label "Anti-PLVAP CSR02-Fab-Tissue Factor" @default.
- NCIT_C178219 subClassOf NCIT_C129821 @default.
- NCIT_C178219 subClassOf NCIT_C178219 @default.
- NCIT_C178219 subClassOf NCIT_C1908 @default.
- NCIT_C178219 subClassOf NCIT_C1909 @default.
- NCIT_C178219 subClassOf NCIT_C1962 @default.
- NCIT_C178219 subClassOf NCIT_C274 @default.
- NCIT_C178219 subClassOf NCIT_C307 @default.
- NCIT_C178219 subClassOf NCIT_C61199 @default.