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- NCIT_C178256 IAO_0000115 "A peptide-drug conjugate composed of the second-generation taxane docetaxel and the sortilin (SORT1)-targeting peptide zendusortide (TH19P01), with potential antineoplastic activity. Upon administration of sudocetaxel zendusortide, the zendusortide moiety targets and binds to SORT1 expressed on tumor cells. Upon internalization, docetaxel binds to and stabilizes the beta-tubulin subunit, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. SORT1 is overexpressed in a variety of cancers and plays an important role in protein internalization, sorting and trafficking." @default.
- NCIT_C178256 NCIT_A7 NCIT_C178267 @default.
- NCIT_C178256 NCIT_NHC0 "C178256" @default.
- NCIT_C178256 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178256 NCIT_P107 "Sudocetaxel Zendusortide" @default.
- NCIT_C178256 NCIT_P108 "Sudocetaxel Zendusortide" @default.
- NCIT_C178256 NCIT_P208 "CL1647955" @default.
- NCIT_C178256 NCIT_P210 "2473125-34-5" @default.
- NCIT_C178256 NCIT_P319 "R52HN99WWC" @default.
- NCIT_C178256 NCIT_P322 "CTRP" @default.
- NCIT_C178256 NCIT_P322 "FDA" @default.
- NCIT_C178256 NCIT_P322 "GDC" @default.
- NCIT_C178256 NCIT_P399 "804860" @default.
- NCIT_C178256 NCIT_R124 NCIT_C17828 @default.
- NCIT_C178256 NCIT_R124 NCIT_C20480 @default.
- NCIT_C178256 NCIT_R124 NCIT_C40795 @default.
- NCIT_C178256 NCIT_R124 NCIT_C40798 @default.
- NCIT_C178256 normalizedInformationContent "100" @default.
- NCIT_C178256 referenceCount "1" @default.
- NCIT_C178256 hasExactSynonym "Docetaxel-TH19P01 Conjugate TH1902" @default.
- NCIT_C178256 hasExactSynonym "SORT1-targeted Docetaxel TH1902" @default.
- NCIT_C178256 hasExactSynonym "SUDOCETAXEL ZENDUSORTIDE" @default.
- NCIT_C178256 hasExactSynonym "Sortilin-targeted Docetaxel TH1902" @default.
- NCIT_C178256 hasExactSynonym "Sudocetaxel Zendusortide" @default.
- NCIT_C178256 hasExactSynonym "TH 1902" @default.
- NCIT_C178256 hasExactSynonym "TH-1902" @default.
- NCIT_C178256 hasExactSynonym "TH1902" @default.
- NCIT_C178256 hasExactSynonym "TH19P01-Docetaxel" @default.
- NCIT_C178256 inSubset NCIT_C116977 @default.
- NCIT_C178256 inSubset NCIT_C116978 @default.
- NCIT_C178256 inSubset NCIT_C128784 @default.
- NCIT_C178256 inSubset NCIT_C157711 @default.
- NCIT_C178256 inSubset NCIT_C157712 @default.
- NCIT_C178256 inSubset NCIT_C176424 @default.
- NCIT_C178256 inSubset NCIT_C63923 @default.
- NCIT_C178256 type Class @default.
- NCIT_C178256 isDefinedBy ncit.owl @default.
- NCIT_C178256 label "Sudocetaxel Zendusortide" @default.
- NCIT_C178256 subClassOf NCIT_C178256 @default.
- NCIT_C178256 subClassOf NCIT_C186664 @default.
- NCIT_C178256 subClassOf NCIT_C1908 @default.
- NCIT_C178256 subClassOf NCIT_C1909 @default.
- NCIT_C178256 subClassOf NCIT_C25974 @default.
- NCIT_C178256 subClassOf NCIT_C273 @default.
- NCIT_C178256 subClassOf NCIT_C274 @default.
- NCIT_C178256 subClassOf NCIT_C67437 @default.