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- NCIT_C178278 IAO_0000115 "A humanized, agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, dalnicastobart targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation of the immune system." @default.
- NCIT_C178278 NCIT_A7 NCIT_C17281 @default.
- NCIT_C178278 NCIT_NHC0 "C178278" @default.
- NCIT_C178278 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178278 NCIT_P107 "Dalnicastobart" @default.
- NCIT_C178278 NCIT_P108 "Dalnicastobart" @default.
- NCIT_C178278 NCIT_P208 "CL1647965" @default.
- NCIT_C178278 NCIT_P210 "2642171-59-1" @default.
- NCIT_C178278 NCIT_P319 "1SN6KFW31L" @default.
- NCIT_C178278 NCIT_P322 "CTRP" @default.
- NCIT_C178278 NCIT_P322 "FDA" @default.
- NCIT_C178278 NCIT_P322 "GDC" @default.
- NCIT_C178278 NCIT_P399 "804716" @default.
- NCIT_C178278 NCIT_R124 NCIT_C17710 @default.
- NCIT_C178278 NCIT_R124 NCIT_C17828 @default.
- NCIT_C178278 NCIT_R124 NCIT_C18219 @default.
- NCIT_C178278 NCIT_R124 NCIT_C19986 @default.
- NCIT_C178278 NCIT_R124 NCIT_C40474 @default.
- NCIT_C178278 normalizedInformationContent "100" @default.
- NCIT_C178278 referenceCount "1" @default.
- NCIT_C178278 hasExactSynonym "Anti-CD40 Agonist Monoclonal Antibody LVGN7409" @default.
- NCIT_C178278 hasExactSynonym "DALNICASTOBART" @default.
- NCIT_C178278 hasExactSynonym "Dalnicastobart" @default.
- NCIT_C178278 hasExactSynonym "LVGN 7409" @default.
- NCIT_C178278 hasExactSynonym "LVGN-7409" @default.
- NCIT_C178278 hasExactSynonym "LVGN7409" @default.
- NCIT_C178278 inSubset NCIT_C116977 @default.
- NCIT_C178278 inSubset NCIT_C116978 @default.
- NCIT_C178278 inSubset NCIT_C128784 @default.
- NCIT_C178278 inSubset NCIT_C157711 @default.
- NCIT_C178278 inSubset NCIT_C157712 @default.
- NCIT_C178278 inSubset NCIT_C176424 @default.
- NCIT_C178278 inSubset NCIT_C63923 @default.
- NCIT_C178278 type Class @default.
- NCIT_C178278 isDefinedBy ncit.owl @default.
- NCIT_C178278 label "Dalnicastobart" @default.
- NCIT_C178278 subClassOf NCIT_C129820 @default.
- NCIT_C178278 subClassOf NCIT_C133877 @default.
- NCIT_C178278 subClassOf NCIT_C178278 @default.
- NCIT_C178278 subClassOf NCIT_C1908 @default.
- NCIT_C178278 subClassOf NCIT_C1909 @default.
- NCIT_C178278 subClassOf NCIT_C191767 @default.
- NCIT_C178278 subClassOf NCIT_C20401 @default.
- NCIT_C178278 subClassOf NCIT_C274 @default.
- NCIT_C178278 subClassOf NCIT_C307 @default.
- NCIT_C178278 subClassOf NCIT_C308 @default.