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- NCIT_C178316 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified to express a nanobody that targets the negative immunoregulatory human cell surface receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous PD-1 nanobody-expressing anti-MSLN CAR T-cells specifically target and kill MSLN-expressing tumor cells. The anti-PD-1 expressed on the CAR T-cells binds to PD-1 expressed on T-cells and prevents the interaction of PD-1 with its ligand programmed cell death 1 ligand 1 (PD-L1, PD-1L1; CD274) expressed on tumor cells. This prevents PD-1-mediated signaling and T-cell exhaustion, enhances T-cell activation, and results in enhanced toxicity in MSLN-expressing tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation and overexpression within the tumor microenvironment (TME) and inhibits T-cell function. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types." @default.
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- NCIT_C178316 NCIT_P108 "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells" @default.
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- NCIT_C178316 hasExactSynonym "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells" @default.
- NCIT_C178316 hasExactSynonym "Autologous PD-1 Nanobody-expressing Anti-Mesothelin CAR-T Cells" @default.
- NCIT_C178316 hasExactSynonym "PD-1 Nanobody-expressing Anti-MSLN CAR T-cells" @default.
- NCIT_C178316 hasExactSynonym "a-PD1-MSLN-CAR T Cells" @default.
- NCIT_C178316 hasExactSynonym "aPD1-MSLN-CAR T Cells" @default.
- NCIT_C178316 hasExactSynonym "alpha-PD1-MSLN-CAR T Cells" @default.
- NCIT_C178316 hasExactSynonym "alphaPD1-MSLN-CAR T Cells" @default.
- NCIT_C178316 inSubset NCIT_C128784 @default.
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- NCIT_C178316 type Class @default.
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- NCIT_C178316 label "Autologous PD-1 Nanobody-expressing Anti-MSLN CAR T-cells" @default.
- NCIT_C178316 subClassOf NCIT_C129820 @default.
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