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- NCIT_C178328 IAO_0000115 "A humanized bispecific antibody composed of a monovalent unit directed against the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2) and a single chain unit directed against CD3 found on T-lymphocytes, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-HER2/anti-CD3 bispecific antibody M802 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and HER2 on HER2-expressing tumor cells. This activates and redirects CTLs to HER2-expressing tumor cells, which results in the CTL-mediated cell death of HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation." @default.
- NCIT_C178328 NCIT_A7 NCIT_C17319 @default.
- NCIT_C178328 NCIT_NHC0 "C178328" @default.
- NCIT_C178328 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178328 NCIT_P108 "Anti-HER2/Anti-CD3 Bispecific Antibody M802" @default.
- NCIT_C178328 NCIT_P208 "CL1647838" @default.
- NCIT_C178328 NCIT_P322 "GDC" @default.
- NCIT_C178328 NCIT_P329 "804162" @default.
- NCIT_C178328 NCIT_P330 "804162" @default.
- NCIT_C178328 NCIT_P399 "804162" @default.
- NCIT_C178328 NCIT_R124 NCIT_C17710 @default.
- NCIT_C178328 NCIT_R124 NCIT_C17828 @default.
- NCIT_C178328 NCIT_R124 NCIT_C18219 @default.
- NCIT_C178328 NCIT_R124 NCIT_C19986 @default.
- NCIT_C178328 NCIT_R124 NCIT_C40474 @default.
- NCIT_C178328 normalizedInformationContent "100" @default.
- NCIT_C178328 referenceCount "1" @default.
- NCIT_C178328 hasExactSynonym "Anti-HER2/Anti-CD3 Bispecific Antibody M802" @default.
- NCIT_C178328 hasExactSynonym "HER2 x CD3 Bispecific Antibody M802" @default.
- NCIT_C178328 hasExactSynonym "M 802" @default.
- NCIT_C178328 hasExactSynonym "M-802" @default.
- NCIT_C178328 hasExactSynonym "M802" @default.
- NCIT_C178328 inSubset NCIT_C128784 @default.
- NCIT_C178328 inSubset NCIT_C157711 @default.
- NCIT_C178328 inSubset NCIT_C157712 @default.
- NCIT_C178328 inSubset NCIT_C176424 @default.
- NCIT_C178328 type Class @default.
- NCIT_C178328 isDefinedBy ncit.owl @default.
- NCIT_C178328 label "Anti-HER2/Anti-CD3 Bispecific Antibody M802" @default.
- NCIT_C178328 subClassOf NCIT_C112883 @default.
- NCIT_C178328 subClassOf NCIT_C129821 @default.
- NCIT_C178328 subClassOf NCIT_C129822 @default.
- NCIT_C178328 subClassOf NCIT_C1454 @default.
- NCIT_C178328 subClassOf NCIT_C155711 @default.
- NCIT_C178328 subClassOf NCIT_C163758 @default.
- NCIT_C178328 subClassOf NCIT_C163760 @default.
- NCIT_C178328 subClassOf NCIT_C178328 @default.
- NCIT_C178328 subClassOf NCIT_C1908 @default.
- NCIT_C178328 subClassOf NCIT_C1909 @default.
- NCIT_C178328 subClassOf NCIT_C201282 @default.
- NCIT_C178328 subClassOf NCIT_C20401 @default.
- NCIT_C178328 subClassOf NCIT_C274 @default.
- NCIT_C178328 subClassOf NCIT_C28227 @default.
- NCIT_C178328 subClassOf NCIT_C307 @default.
- NCIT_C178328 subClassOf NCIT_C308 @default.