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- NCIT_C178329 IAO_0000115 "A radioimmunoconjugate composed of the F(ab')2 fragment of monoclonal antibody MX35 targeting the sodium-dependent phosphate transport protein 2b (NaPi2b; SLC34A2) labeled with the alpha-emitting radionuclide astatine (At) 211 (211At), with potential antineoplastic activity. Upon administration of astatine At 211 F(ab')2 MX35, the F(ab')2 MX35 moiety targets and binds to NaPi2b-expressing tumor cells, thereby delivering a cytotoxic dose of alpha radiation directly to the NaPi2b-expressing tumor cells. NaPi2b, a multi-transmembrane, sodium-dependent phosphate transporter, is highly expressed in certain types of tumor cells." @default.
- NCIT_C178329 NCIT_NHC0 "C178329" @default.
- NCIT_C178329 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C178329 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178329 NCIT_P108 "Astatine At 211 F(ab')2 MX35" @default.
- NCIT_C178329 NCIT_P208 "CL1647839" @default.
- NCIT_C178329 NCIT_P322 "GDC" @default.
- NCIT_C178329 NCIT_P329 "804126" @default.
- NCIT_C178329 NCIT_P330 "804126" @default.
- NCIT_C178329 NCIT_P399 "804126" @default.
- NCIT_C178329 normalizedInformationContent "100" @default.
- NCIT_C178329 referenceCount "1" @default.
- NCIT_C178329 hasExactSynonym "211 At Astatine-labeled MX35 F(ab')2" @default.
- NCIT_C178329 hasExactSynonym "211-Astatine-MX35 F(ab')2" @default.
- NCIT_C178329 hasExactSynonym "Astatine At 211 F(ab')2 MX35" @default.
- NCIT_C178329 hasExactSynonym "Astatine At 211-MX35 F(ab')2" @default.
- NCIT_C178329 hasExactSynonym "At211-MX35 F(ab')2" @default.
- NCIT_C178329 inSubset NCIT_C128784 @default.
- NCIT_C178329 inSubset NCIT_C157711 @default.
- NCIT_C178329 inSubset NCIT_C157712 @default.
- NCIT_C178329 inSubset NCIT_C176424 @default.
- NCIT_C178329 type Class @default.
- NCIT_C178329 isDefinedBy ncit.owl @default.
- NCIT_C178329 label "Astatine At 211 F(ab')2 MX35" @default.
- NCIT_C178329 subClassOf NCIT_C129819 @default.
- NCIT_C178329 subClassOf NCIT_C1446 @default.
- NCIT_C178329 subClassOf NCIT_C1511 @default.
- NCIT_C178329 subClassOf NCIT_C1512 @default.
- NCIT_C178329 subClassOf NCIT_C178329 @default.
- NCIT_C178329 subClassOf NCIT_C1908 @default.
- NCIT_C178329 subClassOf NCIT_C1909 @default.
- NCIT_C178329 subClassOf NCIT_C200225 @default.
- NCIT_C178329 subClassOf NCIT_C2124 @default.
- NCIT_C178329 subClassOf NCIT_C274 @default.
- NCIT_C178329 subClassOf NCIT_C307 @default.
- NCIT_C178329 subClassOf NCIT_C308 @default.