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- NCIT_C178333 IAO_0000115 "A recombinant fusion protein composed of human serum albumin (HSA) fused to human granulocyte colony stimulating factor (G-CSF), with potential granulopoietic activity. Upon administration, recombinant HSA/G-CSF fusion protein MW05 mimics endogenous G-CSF that is produced by monocytes, fibroblasts, and endothelial cells. G-CSF binds to and activates specific cell surface receptors, thereby stimulating the proliferation, differentiation, function, and survival of neutrophil precursors and mature neutrophils. This may prevent granulocytopenia. HSA fusion increases the molecular weight of G-CSF, prolongs its half-life and masks G-CSF, thereby preventing G-CSF degradation which further increases the half-life and bioavailability of G-CSF." @default.
- NCIT_C178333 NCIT_NHC0 "C178333" @default.
- NCIT_C178333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178333 NCIT_P108 "Recombinant HSA/G-CSF Fusion Protein MW05" @default.
- NCIT_C178333 NCIT_P208 "CL1647835" @default.
- NCIT_C178333 NCIT_P329 "804171" @default.
- NCIT_C178333 NCIT_P330 "804171" @default.
- NCIT_C178333 NCIT_P399 "804171" @default.
- NCIT_C178333 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C178333 NCIT_R125 NCIT_C19143 @default.
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- NCIT_C178333 NCIT_R125 NCIT_C20863 @default.
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- NCIT_C178333 NCIT_R125 NCIT_C40702 @default.
- NCIT_C178333 NCIT_R125 NCIT_C40738 @default.
- NCIT_C178333 NCIT_R146 NCIT_C21176 @default.
- NCIT_C178333 NCIT_R146 NCIT_C26548 @default.
- NCIT_C178333 NCIT_R146 NCIT_C38991 @default.
- NCIT_C178333 NCIT_R72 NCIT_C12219 @default.
- NCIT_C178333 NCIT_R72 NCIT_C12508 @default.
- NCIT_C178333 NCIT_R72 NCIT_C12551 @default.
- NCIT_C178333 NCIT_R72 NCIT_C12662 @default.
- NCIT_C178333 NCIT_R72 NCIT_C21599 @default.
- NCIT_C178333 NCIT_R72 NCIT_C32725 @default.
- NCIT_C178333 normalizedInformationContent "100" @default.
- NCIT_C178333 referenceCount "1" @default.
- NCIT_C178333 hasExactSynonym "MW 05" @default.
- NCIT_C178333 hasExactSynonym "MW-05" @default.
- NCIT_C178333 hasExactSynonym "MW05" @default.
- NCIT_C178333 hasExactSynonym "Recombinant HSA/G-CSF Fusion Protein MW05" @default.
- NCIT_C178333 inSubset NCIT_C176424 @default.
- NCIT_C178333 type Class @default.
- NCIT_C178333 isDefinedBy ncit.owl @default.
- NCIT_C178333 label "Recombinant HSA/G-CSF Fusion Protein MW05" @default.
- NCIT_C178333 subClassOf NCIT_C1283 @default.
- NCIT_C178333 subClassOf NCIT_C1287 @default.
- NCIT_C178333 subClassOf NCIT_C178333 @default.
- NCIT_C178333 subClassOf NCIT_C1908 @default.
- NCIT_C178333 subClassOf NCIT_C1909 @default.
- NCIT_C178333 subClassOf NCIT_C2395 @default.
- NCIT_C178333 subClassOf NCIT_C307 @default.
- NCIT_C178333 subClassOf NCIT_C308 @default.
- NCIT_C178333 subClassOf NCIT_C387 @default.
- NCIT_C178333 subClassOf NCIT_C530 @default.