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- NCIT_C178335 IAO_0000115 "A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-Claudin18.2 CAR T cells LCAR-C18S specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C178335 NCIT_A7 NCIT_C150412 @default.
- NCIT_C178335 NCIT_NHC0 "C178335" @default.
- NCIT_C178335 NCIT_P106 "Cell" @default.
- NCIT_C178335 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178335 NCIT_P108 "Anti-Claudin18.2 CAR T Cells LCAR-C18S" @default.
- NCIT_C178335 NCIT_P208 "CL1647833" @default.
- NCIT_C178335 NCIT_P322 "GDC" @default.
- NCIT_C178335 NCIT_P329 "804130" @default.
- NCIT_C178335 NCIT_P330 "804130" @default.
- NCIT_C178335 NCIT_P399 "804130" @default.
- NCIT_C178335 normalizedInformationContent "100" @default.
- NCIT_C178335 referenceCount "1" @default.
- NCIT_C178335 hasExactSynonym "Anti-Claudin18.2 CAR T Cells LCAR-C18S" @default.
- NCIT_C178335 hasExactSynonym "Anti-Claudin18.2-CAR-transduced T Lymphocytes LCAR-C18S" @default.
- NCIT_C178335 hasExactSynonym "LCAR C18S" @default.
- NCIT_C178335 hasExactSynonym "LCAR-C18S" @default.
- NCIT_C178335 hasExactSynonym "LCARC18S" @default.
- NCIT_C178335 inSubset NCIT_C128784 @default.
- NCIT_C178335 inSubset NCIT_C157711 @default.
- NCIT_C178335 inSubset NCIT_C157712 @default.
- NCIT_C178335 inSubset NCIT_C176424 @default.
- NCIT_C178335 type Class @default.
- NCIT_C178335 isDefinedBy ncit.owl @default.
- NCIT_C178335 label "Anti-Claudin18.2 CAR T Cells LCAR-C18S" @default.
- NCIT_C178335 subClassOf NCIT_C129820 @default.
- NCIT_C178335 subClassOf NCIT_C129821 @default.
- NCIT_C178335 subClassOf NCIT_C129826 @default.
- NCIT_C178335 subClassOf NCIT_C137999 @default.
- NCIT_C178335 subClassOf NCIT_C142078 @default.
- NCIT_C178335 subClassOf NCIT_C154231 @default.
- NCIT_C178335 subClassOf NCIT_C178335 @default.
- NCIT_C178335 subClassOf NCIT_C1908 @default.
- NCIT_C178335 subClassOf NCIT_C1909 @default.
- NCIT_C178335 subClassOf NCIT_C1962 @default.
- NCIT_C178335 subClassOf NCIT_C201172 @default.
- NCIT_C178335 subClassOf NCIT_C274 @default.
- NCIT_C178335 subClassOf NCIT_C307 @default.
- NCIT_C178335 subClassOf NCIT_C308 @default.