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- NCIT_C178337 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to encode a T-cell receptor (TCR) specific for Epstein-Barr virus (EBV) latent membrane protein (LMP) 2, with potential antineoplastic activity. Upon administration, the LMP2-specific IL-12 secreting TCR-transduced T-lymphocytes (TCR-T) recognize and bind to EBV LMP2, which may promote cell death and inhibit the growth of tumor cells expressing LMP2. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in LMP2-expressing tumor cells. As a tumor associated antigen (TAA), LMP2 is expressed in various EBV-associated malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma." @default.
- NCIT_C178337 NCIT_A7 NCIT_C177543 @default.
- NCIT_C178337 NCIT_NHC0 "C178337" @default.
- NCIT_C178337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178337 NCIT_P108 "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes" @default.
- NCIT_C178337 NCIT_P208 "CL1647831" @default.
- NCIT_C178337 NCIT_P322 "GDC" @default.
- NCIT_C178337 NCIT_P329 "804175" @default.
- NCIT_C178337 NCIT_P330 "804175" @default.
- NCIT_C178337 NCIT_P399 "804175" @default.
- NCIT_C178337 normalizedInformationContent "100" @default.
- NCIT_C178337 referenceCount "1" @default.
- NCIT_C178337 hasExactSynonym "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-cells" @default.
- NCIT_C178337 hasExactSynonym "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes" @default.
- NCIT_C178337 hasExactSynonym "LMP2-specific IL-12 Secreting TCR-T Cells" @default.
- NCIT_C178337 hasExactSynonym "LMP2-specific IL-12 Secreting TCR-transduced T-lymphocytes" @default.
- NCIT_C178337 inSubset NCIT_C128784 @default.
- NCIT_C178337 inSubset NCIT_C157711 @default.
- NCIT_C178337 inSubset NCIT_C157712 @default.
- NCIT_C178337 inSubset NCIT_C176424 @default.
- NCIT_C178337 type Class @default.
- NCIT_C178337 isDefinedBy ncit.owl @default.
- NCIT_C178337 label "LMP2-specific IL-12 Secreting T Cell Receptor-transduced T-lymphocytes" @default.
- NCIT_C178337 subClassOf NCIT_C129820 @default.
- NCIT_C178337 subClassOf NCIT_C129821 @default.
- NCIT_C178337 subClassOf NCIT_C129826 @default.
- NCIT_C178337 subClassOf NCIT_C138180 @default.
- NCIT_C178337 subClassOf NCIT_C142078 @default.
- NCIT_C178337 subClassOf NCIT_C154231 @default.
- NCIT_C178337 subClassOf NCIT_C178337 @default.
- NCIT_C178337 subClassOf NCIT_C1908 @default.
- NCIT_C178337 subClassOf NCIT_C1909 @default.
- NCIT_C178337 subClassOf NCIT_C1962 @default.
- NCIT_C178337 subClassOf NCIT_C274 @default.
- NCIT_C178337 subClassOf NCIT_C307 @default.
- NCIT_C178337 subClassOf NCIT_C308 @default.