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- NCIT_C178343 IAO_0000115 "An inhibitor of signal transducer and activator of transcription 3 (STAT3) and insulin receptor substrate 1 (IRS1) and 2 (IRS2), with potential antineoplastic activity. Upon administration, the IRS1/IRS2/STAT3 inhibitor NT219 specifically targets and binds to IRS1/2 and STAT3. Inhibiting IRS1/2 prevents IRS1/2-mediated signaling pathways and other tumor survival pathways. Inhibiting STAT3 prevents nuclear translocation of STAT3 and the STAT3-mediated regulation of oncogenes expression. This causes tumor cell apoptosis and inhibits tumor cell proliferation. IRS1/2 and STAT3, oncogenic drivers that are upregulated in a variety of human cancers, play key roles in uncontrolled tumor cell proliferation and tumor resistance." @default.
- NCIT_C178343 NCIT_A7 NCIT_C28474 @default.
- NCIT_C178343 NCIT_A7 NCIT_C28475 @default.
- NCIT_C178343 NCIT_A7 NCIT_C28664 @default.
- NCIT_C178343 NCIT_NHC0 "C178343" @default.
- NCIT_C178343 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178343 NCIT_P107 "IRS1/IRS2/STAT3 Inhibitor NT219" @default.
- NCIT_C178343 NCIT_P108 "IRS1/IRS2/STAT3 Inhibitor NT219" @default.
- NCIT_C178343 NCIT_P208 "CL1647825" @default.
- NCIT_C178343 NCIT_P210 "1198078-60-2" @default.
- NCIT_C178343 NCIT_P319 "K1WT1A1UP5" @default.
- NCIT_C178343 NCIT_P322 "CTRP" @default.
- NCIT_C178343 NCIT_P322 "FDA" @default.
- NCIT_C178343 NCIT_P322 "GDC" @default.
- NCIT_C178343 NCIT_P329 "804135" @default.
- NCIT_C178343 NCIT_P330 "804135" @default.
- NCIT_C178343 NCIT_P399 "804135" @default.
- NCIT_C178343 normalizedInformationContent "100" @default.
- NCIT_C178343 referenceCount "1" @default.
- NCIT_C178343 hasExactSynonym "IRS1/IRS2/STAT3 Inhibitor NT219" @default.
- NCIT_C178343 hasExactSynonym "NT 219" @default.
- NCIT_C178343 hasExactSynonym "NT-219" @default.
- NCIT_C178343 hasExactSynonym "NT219" @default.
- NCIT_C178343 inSubset NCIT_C116977 @default.
- NCIT_C178343 inSubset NCIT_C116978 @default.
- NCIT_C178343 inSubset NCIT_C128784 @default.
- NCIT_C178343 inSubset NCIT_C157711 @default.
- NCIT_C178343 inSubset NCIT_C157712 @default.
- NCIT_C178343 inSubset NCIT_C176424 @default.
- NCIT_C178343 inSubset NCIT_C63923 @default.
- NCIT_C178343 type Class @default.
- NCIT_C178343 isDefinedBy ncit.owl @default.
- NCIT_C178343 label "IRS1/IRS2/STAT3 Inhibitor NT219" @default.
- NCIT_C178343 subClassOf NCIT_C178343 @default.
- NCIT_C178343 subClassOf NCIT_C1908 @default.
- NCIT_C178343 subClassOf NCIT_C1909 @default.
- NCIT_C178343 subClassOf NCIT_C2189 @default.
- NCIT_C178343 subClassOf NCIT_C274 @default.