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- NCIT_C178397 IAO_0000115 "A Bicycle toxin conjugate (BTC) composed of a synthetic, bicyclic peptide targeting the cell adhesion molecule nectin-4 (PVRL4) and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via an inert sarcosine spacer chain and a valine-citrulline cleavable linker, with potential antineoplastic activity. Upon administration, the bicyclic peptide moiety of Nectin-4-targeting bicyclic peptide/MMAE BT8009 selectively binds to nectin-4. After internalization and proteolytic cleavage by peptidases that are upregulated in the tumor microenvironment (TME), MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen (TAA) belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue. It is associated with poor disease prognosis." @default.
- NCIT_C178397 NCIT_A7 NCIT_C134483 @default.
- NCIT_C178397 NCIT_NHC0 "C178397" @default.
- NCIT_C178397 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178397 NCIT_P107 "Nectin-4-targeting Bicyclic Peptide/MMAE BT8009" @default.
- NCIT_C178397 NCIT_P108 "Nectin-4-targeting Bicyclic Peptide/MMAE BT8009" @default.
- NCIT_C178397 NCIT_P208 "CL1647869" @default.
- NCIT_C178397 NCIT_P322 "CTRP" @default.
- NCIT_C178397 NCIT_P322 "GDC" @default.
- NCIT_C178397 NCIT_P329 "804521" @default.
- NCIT_C178397 NCIT_P330 "804521" @default.
- NCIT_C178397 NCIT_P399 "804521" @default.
- NCIT_C178397 normalizedInformationContent "100" @default.
- NCIT_C178397 referenceCount "1" @default.
- NCIT_C178397 hasExactSynonym "BT 8009" @default.
- NCIT_C178397 hasExactSynonym "BT-8009" @default.
- NCIT_C178397 hasExactSynonym "BT8009" @default.
- NCIT_C178397 hasExactSynonym "BTC BT8009" @default.
- NCIT_C178397 hasExactSynonym "Bicycle Toxin Conjugate BT8009" @default.
- NCIT_C178397 hasExactSynonym "Bicycle-MMAE BT8009" @default.
- NCIT_C178397 hasExactSynonym "Nectin-4-binding Bicycle-MMAE BT8009" @default.
- NCIT_C178397 hasExactSynonym "Nectin-4-targeting Bicyclic Peptide Toxin Conjugate BT8009" @default.
- NCIT_C178397 hasExactSynonym "Nectin-4-targeting Bicyclic Peptide/MMAE BT8009" @default.
- NCIT_C178397 hasExactSynonym "PVRL4-targeting Bicyclic Peptide Toxin Conjugate BT8009" @default.
- NCIT_C178397 inSubset NCIT_C116977 @default.
- NCIT_C178397 inSubset NCIT_C116978 @default.
- NCIT_C178397 inSubset NCIT_C128784 @default.
- NCIT_C178397 inSubset NCIT_C157711 @default.
- NCIT_C178397 inSubset NCIT_C157712 @default.
- NCIT_C178397 inSubset NCIT_C176424 @default.
- NCIT_C178397 type Class @default.
- NCIT_C178397 isDefinedBy ncit.owl @default.
- NCIT_C178397 label "Nectin-4-targeting Bicyclic Peptide/MMAE BT8009" @default.
- NCIT_C178397 subClassOf NCIT_C1512 @default.
- NCIT_C178397 subClassOf NCIT_C178397 @default.
- NCIT_C178397 subClassOf NCIT_C1908 @default.
- NCIT_C178397 subClassOf NCIT_C1909 @default.
- NCIT_C178397 subClassOf NCIT_C307 @default.
- NCIT_C178397 subClassOf NCIT_C308 @default.