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- NCIT_C178398 IAO_0000115 "A bifunctional fusion protein composed of an anti-programmed death ligand 1 (PD-L1) monoclonal antibody bound, via the C-terminal ends of the Fc region, to the N-terminal-truncated extracellular domain (ECD) of human transforming growth factor beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating activities. Upon administration, retlirafusp alfa targets, binds to and neutralizes TGFbeta on the tumor cell while the antibody moiety simultaneously targets, binds to, and inhibits the activity of PD-L1 on the tumor cell. This prevents both TGFbeta- and PD-L1-mediated immuno-suppressive pathways signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This restores and enhances anti-tumor responses and inhibits tumor cell proliferation in susceptible tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers; their overexpression is associated with increased evasion of immune surveillance and contributes to poor prognosis." @default.
- NCIT_C178398 NCIT_A7 NCIT_C20457 @default.
- NCIT_C178398 NCIT_A7 NCIT_C20458 @default.
- NCIT_C178398 NCIT_A7 NCIT_C20459 @default.
- NCIT_C178398 NCIT_A7 NCIT_C96024 @default.
- NCIT_C178398 NCIT_NHC0 "C178398" @default.
- NCIT_C178398 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178398 NCIT_P108 "Retlirafusp Alfa" @default.
- NCIT_C178398 NCIT_P208 "CL1647870" @default.
- NCIT_C178398 NCIT_P210 "2395839-91-3" @default.
- NCIT_C178398 NCIT_P319 "JP6N6TA92L" @default.
- NCIT_C178398 NCIT_P322 "FDA" @default.
- NCIT_C178398 NCIT_P322 "GDC" @default.
- NCIT_C178398 NCIT_P329 "797049" @default.
- NCIT_C178398 NCIT_P330 "797049" @default.
- NCIT_C178398 NCIT_P399 "797049" @default.
- NCIT_C178398 normalizedInformationContent "100" @default.
- NCIT_C178398 referenceCount "1" @default.
- NCIT_C178398 hasExactSynonym "Anti-PD-L1/TGF-betaRII Fusion Protein SHR 1701" @default.
- NCIT_C178398 hasExactSynonym "PD-L1 / TGF-b-targeting Fusion Protein SHR 1701" @default.
- NCIT_C178398 hasExactSynonym "PDL1 x TGFb-targeting Bifunctional Fusion Protein SHR 1701" @default.
- NCIT_C178398 hasExactSynonym "RETLIRAFUSP ALFA" @default.
- NCIT_C178398 hasExactSynonym "Retlirafusp Alfa" @default.
- NCIT_C178398 hasExactSynonym "SHR 1701" @default.
- NCIT_C178398 hasExactSynonym "SHR-1701" @default.
- NCIT_C178398 hasExactSynonym "SHR1701" @default.
- NCIT_C178398 inSubset NCIT_C128784 @default.
- NCIT_C178398 inSubset NCIT_C157711 @default.
- NCIT_C178398 inSubset NCIT_C157712 @default.
- NCIT_C178398 inSubset NCIT_C176424 @default.
- NCIT_C178398 inSubset NCIT_C63923 @default.
- NCIT_C178398 type Class @default.
- NCIT_C178398 isDefinedBy ncit.owl @default.
- NCIT_C178398 label "Retlirafusp Alfa" @default.
- NCIT_C178398 subClassOf NCIT_C129821 @default.
- NCIT_C178398 subClassOf NCIT_C178398 @default.
- NCIT_C178398 subClassOf NCIT_C1908 @default.
- NCIT_C178398 subClassOf NCIT_C1909 @default.
- NCIT_C178398 subClassOf NCIT_C274 @default.
- NCIT_C178398 subClassOf NCIT_C307 @default.