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- NCIT_C178399 IAO_0000115 "A cancer cell metabolism modulator, with potential antineoplastic activity. Upon administration, OMT-111 inhibits pyruvate dehydrogenase kinase (PDH), resulting in the activation of the citric acid cycle in mitochondria, which leads to the degradation of hypoxia-inducible factor 1-alpha (HIF1A). This may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. OMT-111 may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling." @default.
- NCIT_C178399 NCIT_A7 NCIT_C74443 @default.
- NCIT_C178399 NCIT_NHC0 "C178399" @default.
- NCIT_C178399 NCIT_P106 "Organic Chemical" @default.
- NCIT_C178399 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178399 NCIT_P108 "Cancer Cell Metabolism Modulator OMT-111" @default.
- NCIT_C178399 NCIT_P208 "CL1647867" @default.
- NCIT_C178399 NCIT_P322 "GDC" @default.
- NCIT_C178399 NCIT_P329 "804179" @default.
- NCIT_C178399 NCIT_P330 "804179" @default.
- NCIT_C178399 NCIT_P399 "804179" @default.
- NCIT_C178399 normalizedInformationContent "100" @default.
- NCIT_C178399 referenceCount "1" @default.
- NCIT_C178399 hasExactSynonym "Cancer Cell Metabolism Modulator OMT-111" @default.
- NCIT_C178399 hasExactSynonym "OMT 111" @default.
- NCIT_C178399 hasExactSynonym "OMT-111" @default.
- NCIT_C178399 hasExactSynonym "OMT111" @default.
- NCIT_C178399 inSubset NCIT_C128784 @default.
- NCIT_C178399 inSubset NCIT_C157711 @default.
- NCIT_C178399 inSubset NCIT_C157712 @default.
- NCIT_C178399 inSubset NCIT_C176424 @default.
- NCIT_C178399 type Class @default.
- NCIT_C178399 isDefinedBy ncit.owl @default.
- NCIT_C178399 label "Cancer Cell Metabolism Modulator OMT-111" @default.
- NCIT_C178399 subClassOf NCIT_C129820 @default.
- NCIT_C178399 subClassOf NCIT_C177430 @default.
- NCIT_C178399 subClassOf NCIT_C178399 @default.
- NCIT_C178399 subClassOf NCIT_C1908 @default.
- NCIT_C178399 subClassOf NCIT_C1909 @default.
- NCIT_C178399 subClassOf NCIT_C274 @default.
- NCIT_C178399 subClassOf NCIT_C308 @default.