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- NCIT_C178401 IAO_0000115 "An orally bioavailable selective inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. Upon administration, risovalisib selectively targets, binds to and inhibits wild-type PIK3CA and its mutated forms, in the PI3K/Akt (protein kinase B) /mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, this agent may be more efficacious and less toxic than pan-PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K." @default.
- NCIT_C178401 NCIT_A7 NCIT_C30168 @default.
- NCIT_C178401 NCIT_NHC0 "C178401" @default.
- NCIT_C178401 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178401 NCIT_P108 "Risovalisib" @default.
- NCIT_C178401 NCIT_P208 "CL1647865" @default.
- NCIT_C178401 NCIT_P210 "1494684-28-4" @default.
- NCIT_C178401 NCIT_P319 "RCA38L4HB5" @default.
- NCIT_C178401 NCIT_P322 "FDA" @default.
- NCIT_C178401 NCIT_P322 "GDC" @default.
- NCIT_C178401 NCIT_P329 "804500" @default.
- NCIT_C178401 NCIT_P330 "804500" @default.
- NCIT_C178401 NCIT_P399 "804500" @default.
- NCIT_C178401 normalizedInformationContent "100" @default.
- NCIT_C178401 referenceCount "1" @default.
- NCIT_C178401 hasExactSynonym "CYH 33" @default.
- NCIT_C178401 hasExactSynonym "CYH-33" @default.
- NCIT_C178401 hasExactSynonym "CYH33" @default.
- NCIT_C178401 hasExactSynonym "HH-CYH33" @default.
- NCIT_C178401 hasExactSynonym "HHCYH 33" @default.
- NCIT_C178401 hasExactSynonym "PI3K-alpha Inhibitor CYH33" @default.
- NCIT_C178401 hasExactSynonym "PI3Kalpha Inhibitor CYH33" @default.
- NCIT_C178401 hasExactSynonym "RISOVALISIB" @default.
- NCIT_C178401 hasExactSynonym "Risovalisib" @default.
- NCIT_C178401 inSubset NCIT_C128784 @default.
- NCIT_C178401 inSubset NCIT_C157711 @default.
- NCIT_C178401 inSubset NCIT_C157712 @default.
- NCIT_C178401 inSubset NCIT_C176424 @default.
- NCIT_C178401 inSubset NCIT_C63923 @default.
- NCIT_C178401 type Class @default.
- NCIT_C178401 isDefinedBy ncit.owl @default.
- NCIT_C178401 label "Risovalisib" @default.
- NCIT_C178401 subClassOf NCIT_C129824 @default.
- NCIT_C178401 subClassOf NCIT_C129825 @default.
- NCIT_C178401 subClassOf NCIT_C1404 @default.
- NCIT_C178401 subClassOf NCIT_C163758 @default.
- NCIT_C178401 subClassOf NCIT_C1742 @default.
- NCIT_C178401 subClassOf NCIT_C178401 @default.
- NCIT_C178401 subClassOf NCIT_C1908 @default.
- NCIT_C178401 subClassOf NCIT_C1909 @default.
- NCIT_C178401 subClassOf NCIT_C2152 @default.
- NCIT_C178401 subClassOf NCIT_C2189 @default.
- NCIT_C178401 subClassOf NCIT_C274 @default.
- NCIT_C178401 subClassOf NCIT_C471 @default.