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- NCIT_C178408 IAO_0000115 "A human bispecific antibody, with potential antineoplastic activity. Anti-CD22/CD3 bispecific antibody JNJ-75348780 contains two binding sites, one for the tumor-associated antigen (TAA) CD22, and one for the T-cell surface antigen CD3. Upon administration, JNJ-75348780 binds to both CD3 on T-cells and CD22-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD22-expressing tumor B-cells. CD22 is exclusively expressed on B-cells and is often overexpressed in B-lymphocytic malignancies. It negatively regulates the B-cell receptor." @default.
- NCIT_C178408 NCIT_A7 NCIT_C17279 @default.
- NCIT_C178408 NCIT_NHC0 "C178408" @default.
- NCIT_C178408 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C178408 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178408 NCIT_P108 "Anti-CD22/CD3 Bispecific Antibody JNJ-75348780" @default.
- NCIT_C178408 NCIT_P208 "CL1647860" @default.
- NCIT_C178408 NCIT_P322 "GDC" @default.
- NCIT_C178408 NCIT_P329 "804516" @default.
- NCIT_C178408 NCIT_P330 "804516" @default.
- NCIT_C178408 NCIT_P399 "804516" @default.
- NCIT_C178408 NCIT_R124 NCIT_C17710 @default.
- NCIT_C178408 NCIT_R124 NCIT_C17828 @default.
- NCIT_C178408 NCIT_R124 NCIT_C18219 @default.
- NCIT_C178408 NCIT_R124 NCIT_C19986 @default.
- NCIT_C178408 NCIT_R124 NCIT_C40474 @default.
- NCIT_C178408 normalizedInformationContent "100" @default.
- NCIT_C178408 referenceCount "1" @default.
- NCIT_C178408 hasExactSynonym "Anti-CD22/CD3 Bispecific Antibody JNJ-75348780" @default.
- NCIT_C178408 hasExactSynonym "CD22 x CD3 Bispecific Antibody JNJ-75348780" @default.
- NCIT_C178408 hasExactSynonym "JNJ 75348780" @default.
- NCIT_C178408 hasExactSynonym "JNJ-75348780" @default.
- NCIT_C178408 hasExactSynonym "JNJ75348780" @default.
- NCIT_C178408 inSubset NCIT_C128784 @default.
- NCIT_C178408 inSubset NCIT_C157711 @default.
- NCIT_C178408 inSubset NCIT_C157712 @default.
- NCIT_C178408 inSubset NCIT_C176424 @default.
- NCIT_C178408 type Class @default.
- NCIT_C178408 isDefinedBy ncit.owl @default.
- NCIT_C178408 label "Anti-CD22/CD3 Bispecific Antibody JNJ-75348780" @default.
- NCIT_C178408 subClassOf NCIT_C112883 @default.
- NCIT_C178408 subClassOf NCIT_C1454 @default.
- NCIT_C178408 subClassOf NCIT_C178408 @default.
- NCIT_C178408 subClassOf NCIT_C1908 @default.
- NCIT_C178408 subClassOf NCIT_C1909 @default.
- NCIT_C178408 subClassOf NCIT_C201282 @default.
- NCIT_C178408 subClassOf NCIT_C20401 @default.
- NCIT_C178408 subClassOf NCIT_C28227 @default.
- NCIT_C178408 subClassOf NCIT_C307 @default.
- NCIT_C178408 subClassOf NCIT_C308 @default.