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- NCIT_C178410 IAO_0000115 "An antibody-drug conjugate (ADC) containing a humanized immunoglobulin G1 kappa (IgG1k) monoclonal antibody directed against prostate-specific membrane antigen (PSMA) and site-specifically conjugated to two of the microtubule-disrupting toxin amberstatin (AS269), with potential antineoplastic activity. Upon administration of anti-PSMA ADC ARX517, the monoclonal antibody moiety selectively binds to PSMA, a protein which is abundantly expressed on the surface of metastatic and hormone-refractory prostate cancer cells. Upon internalization, amberstatin binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. The site-specific conjugation of the cytotoxic agent to the antibody improves the biophysical properties of ARX517, increases payload stability and optimizes its efficacy." @default.
- NCIT_C178410 NCIT_A7 NCIT_C17796 @default.
- NCIT_C178410 NCIT_NHC0 "C178410" @default.
- NCIT_C178410 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178410 NCIT_P108 "Anti-PSMA Antibody-drug Conjugate ARX517" @default.
- NCIT_C178410 NCIT_P208 "CL1647858" @default.
- NCIT_C178410 NCIT_P322 "GDC" @default.
- NCIT_C178410 NCIT_P329 "804520" @default.
- NCIT_C178410 NCIT_P330 "804520" @default.
- NCIT_C178410 NCIT_P399 "804520" @default.
- NCIT_C178410 normalizedInformationContent "100" @default.
- NCIT_C178410 referenceCount "1" @default.
- NCIT_C178410 hasExactSynonym "ADC ARX517" @default.
- NCIT_C178410 hasExactSynonym "ARX 517" @default.
- NCIT_C178410 hasExactSynonym "ARX517" @default.
- NCIT_C178410 hasExactSynonym "Anti-PSMA ADC ARX517" @default.
- NCIT_C178410 hasExactSynonym "Anti-PSMA Antibody-drug Conjugate ARX517" @default.
- NCIT_C178410 hasExactSynonym "Anti-PSMA/AS269 ADC ARX517" @default.
- NCIT_C178410 inSubset NCIT_C128784 @default.
- NCIT_C178410 inSubset NCIT_C157711 @default.
- NCIT_C178410 inSubset NCIT_C157712 @default.
- NCIT_C178410 inSubset NCIT_C176424 @default.
- NCIT_C178410 type Class @default.
- NCIT_C178410 isDefinedBy ncit.owl @default.
- NCIT_C178410 label "Anti-PSMA Antibody-drug Conjugate ARX517" @default.
- NCIT_C178410 subClassOf NCIT_C129821 @default.
- NCIT_C178410 subClassOf NCIT_C129823 @default.
- NCIT_C178410 subClassOf NCIT_C1512 @default.
- NCIT_C178410 subClassOf NCIT_C163758 @default.
- NCIT_C178410 subClassOf NCIT_C176017 @default.
- NCIT_C178410 subClassOf NCIT_C178410 @default.
- NCIT_C178410 subClassOf NCIT_C1908 @default.
- NCIT_C178410 subClassOf NCIT_C1909 @default.
- NCIT_C178410 subClassOf NCIT_C201544 @default.
- NCIT_C178410 subClassOf NCIT_C274 @default.
- NCIT_C178410 subClassOf NCIT_C307 @default.
- NCIT_C178410 subClassOf NCIT_C308 @default.