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- NCIT_C178424 IAO_0000115 "A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic CD20 CAR-grafted gamma delta T-cells ADI-001 specifically target and bind to tumor cells expressing CD20. This induces secretion of pro-inflammatory cytokines and results in the lysis of CD20-expressing tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies." @default.
- NCIT_C178424 NCIT_A7 NCIT_C38896 @default.
- NCIT_C178424 NCIT_NHC0 "C178424" @default.
- NCIT_C178424 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178424 NCIT_P107 "Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001" @default.
- NCIT_C178424 NCIT_P108 "Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001" @default.
- NCIT_C178424 NCIT_P208 "CL1648148" @default.
- NCIT_C178424 NCIT_P322 "CTRP" @default.
- NCIT_C178424 NCIT_P322 "GDC" @default.
- NCIT_C178424 NCIT_P399 "804924" @default.
- NCIT_C178424 normalizedInformationContent "100" @default.
- NCIT_C178424 referenceCount "1" @default.
- NCIT_C178424 hasExactSynonym "ADI 001" @default.
- NCIT_C178424 hasExactSynonym "ADI-001" @default.
- NCIT_C178424 hasExactSynonym "ADI001" @default.
- NCIT_C178424 hasExactSynonym "Allogeneic Anti-CD20 CAR-engineered Gamma Delta T Cells ADI-001" @default.
- NCIT_C178424 hasExactSynonym "Allogeneic Anti-CD20-CAR Gamma Delta T-lymphocytes ADI-001" @default.
- NCIT_C178424 hasExactSynonym "Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001" @default.
- NCIT_C178424 inSubset NCIT_C116977 @default.
- NCIT_C178424 inSubset NCIT_C116978 @default.
- NCIT_C178424 inSubset NCIT_C128784 @default.
- NCIT_C178424 inSubset NCIT_C157711 @default.
- NCIT_C178424 inSubset NCIT_C157712 @default.
- NCIT_C178424 inSubset NCIT_C176424 @default.
- NCIT_C178424 type Class @default.
- NCIT_C178424 isDefinedBy ncit.owl @default.
- NCIT_C178424 label "Allogeneic CD20 CAR-grafted Gamma Delta T-cells ADI-001" @default.
- NCIT_C178424 subClassOf NCIT_C129820 @default.
- NCIT_C178424 subClassOf NCIT_C129821 @default.
- NCIT_C178424 subClassOf NCIT_C129826 @default.
- NCIT_C178424 subClassOf NCIT_C137999 @default.
- NCIT_C178424 subClassOf NCIT_C142078 @default.
- NCIT_C178424 subClassOf NCIT_C154231 @default.
- NCIT_C178424 subClassOf NCIT_C178424 @default.
- NCIT_C178424 subClassOf NCIT_C1908 @default.
- NCIT_C178424 subClassOf NCIT_C1909 @default.
- NCIT_C178424 subClassOf NCIT_C1962 @default.
- NCIT_C178424 subClassOf NCIT_C200765 @default.
- NCIT_C178424 subClassOf NCIT_C201174 @default.
- NCIT_C178424 subClassOf NCIT_C274 @default.
- NCIT_C178424 subClassOf NCIT_C28676 @default.
- NCIT_C178424 subClassOf NCIT_C307 @default.
- NCIT_C178424 subClassOf NCIT_C308 @default.