Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C178432> ?p ?o ?g. }
Showing items 1 to 34 of
34
with 100 items per page.
- NCIT_C178432 IAO_0000115 "An mRNA-based, personalized cancer vaccine consisting of total tumor RNA (TTRNA) derived and amplified from autologous tumor cells and mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion protein with the full-length lysosome-associated membrane protein (flLAMP), formulated in DOTAP lipid particles, with potential immunostimulatory and antineoplastic activities. Upon administration of the autologous total tumor mRNA and CMV-pp65-flLAMP mRNA loaded liposome vaccine, the mRNA is taken up, translated and presented by antigen presenting cells (APCs). This leads to an induction of both cytotoxic T-lymphocyte and memory T-cell dependent immune responses that specifically target and destroy the patient's cancer cells that express these tumor antigens. The incorporation of flLAMP may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped subviral particle of CMV and is expressed in certain tumor types." @default.
- NCIT_C178432 NCIT_A7 NCIT_C141213 @default.
- NCIT_C178432 NCIT_NHC0 "C178432" @default.
- NCIT_C178432 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178432 NCIT_P108 "Autologous Total Tumor mRNA and CMV-pp65-flLAMP mRNA Loaded Liposome Vaccine" @default.
- NCIT_C178432 NCIT_P208 "CL1648134" @default.
- NCIT_C178432 NCIT_P322 "GDC" @default.
- NCIT_C178432 NCIT_P329 "804531" @default.
- NCIT_C178432 NCIT_P330 "804531" @default.
- NCIT_C178432 NCIT_P399 "804531" @default.
- NCIT_C178432 normalizedInformationContent "100" @default.
- NCIT_C178432 referenceCount "1" @default.
- NCIT_C178432 hasExactSynonym "Autologous Total Tumor mRNA and CMV-pp65-flLAMP mRNA Loaded Lipid Particles" @default.
- NCIT_C178432 hasExactSynonym "Autologous Total Tumor mRNA and CMV-pp65-flLAMP mRNA Loaded Liposome Vaccine" @default.
- NCIT_C178432 hasExactSynonym "Autologous Total Tumor mRNA/CMV-pp65-flLAMP mRNA-LPs" @default.
- NCIT_C178432 hasExactSynonym "Autologous Total Tumor mRNA/CMV-pp65-flLAMP mRNA-loaded DOTAP Liposome Vaccine" @default.
- NCIT_C178432 inSubset NCIT_C128784 @default.
- NCIT_C178432 inSubset NCIT_C157711 @default.
- NCIT_C178432 inSubset NCIT_C157712 @default.
- NCIT_C178432 inSubset NCIT_C176424 @default.
- NCIT_C178432 type Class @default.
- NCIT_C178432 isDefinedBy ncit.owl @default.
- NCIT_C178432 label "Autologous Total Tumor mRNA and CMV-pp65-flLAMP mRNA Loaded Liposome Vaccine" @default.
- NCIT_C178432 subClassOf NCIT_C129820 @default.
- NCIT_C178432 subClassOf NCIT_C1663 @default.
- NCIT_C178432 subClassOf NCIT_C172787 @default.
- NCIT_C178432 subClassOf NCIT_C178432 @default.
- NCIT_C178432 subClassOf NCIT_C181141 @default.
- NCIT_C178432 subClassOf NCIT_C1908 @default.
- NCIT_C178432 subClassOf NCIT_C1909 @default.
- NCIT_C178432 subClassOf NCIT_C274 @default.
- NCIT_C178432 subClassOf NCIT_C307 @default.
- NCIT_C178432 subClassOf NCIT_C308 @default.
- NCIT_C178432 subClassOf NCIT_C923 @default.