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- NCIT_C178434 IAO_0000115 "A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with genetic modification of CD52 and T-cell receptor alpha constant (TRAC) loci via clustered regularly interspaced short palindromic repeats (CRISPR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-CD19 CAR T cells PBLTT52CAR19 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The editing of the CD52 gene may make the modified donor T-cells resistant to the anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. The editing of the TRAC may eliminate TCR expression, which may abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells, and may also result in uniform CAR expression and enhanced T-cell potency." @default.
- NCIT_C178434 NCIT_A7 NCIT_C38894 @default.
- NCIT_C178434 NCIT_NHC0 "C178434" @default.
- NCIT_C178434 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178434 NCIT_P108 "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19" @default.
- NCIT_C178434 NCIT_P208 "CL1648136" @default.
- NCIT_C178434 NCIT_P322 "GDC" @default.
- NCIT_C178434 NCIT_P329 "804539" @default.
- NCIT_C178434 NCIT_P330 "804539" @default.
- NCIT_C178434 NCIT_P399 "804539" @default.
- NCIT_C178434 normalizedInformationContent "100" @default.
- NCIT_C178434 referenceCount "1" @default.
- NCIT_C178434 hasExactSynonym "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19" @default.
- NCIT_C178434 hasExactSynonym "Allogeneic CRISPR-edited Anti-CD19 CAR T-cells PBLTT52CAR19" @default.
- NCIT_C178434 hasExactSynonym "Allogeneic CRISPR-edited Anti-CD19 CAR-T Cells PBLTT52CAR19" @default.
- NCIT_C178434 hasExactSynonym "PBLTT52 CAR19" @default.
- NCIT_C178434 hasExactSynonym "PBLTT52-CAR19" @default.
- NCIT_C178434 hasExactSynonym "PBLTT52CAR19" @default.
- NCIT_C178434 inSubset NCIT_C128784 @default.
- NCIT_C178434 inSubset NCIT_C157711 @default.
- NCIT_C178434 inSubset NCIT_C157712 @default.
- NCIT_C178434 inSubset NCIT_C176424 @default.
- NCIT_C178434 type Class @default.
- NCIT_C178434 isDefinedBy ncit.owl @default.
- NCIT_C178434 label "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19" @default.
- NCIT_C178434 subClassOf NCIT_C129820 @default.
- NCIT_C178434 subClassOf NCIT_C129821 @default.
- NCIT_C178434 subClassOf NCIT_C129826 @default.
- NCIT_C178434 subClassOf NCIT_C137999 @default.
- NCIT_C178434 subClassOf NCIT_C142078 @default.
- NCIT_C178434 subClassOf NCIT_C154231 @default.
- NCIT_C178434 subClassOf NCIT_C176018 @default.
- NCIT_C178434 subClassOf NCIT_C178434 @default.
- NCIT_C178434 subClassOf NCIT_C1908 @default.
- NCIT_C178434 subClassOf NCIT_C1909 @default.
- NCIT_C178434 subClassOf NCIT_C1962 @default.
- NCIT_C178434 subClassOf NCIT_C200765 @default.
- NCIT_C178434 subClassOf NCIT_C274 @default.
- NCIT_C178434 subClassOf NCIT_C28676 @default.
- NCIT_C178434 subClassOf NCIT_C307 @default.
- NCIT_C178434 subClassOf NCIT_C308 @default.