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- NCIT_C178436 IAO_0000115 "An orally bioavailable, small molecule Toll-Like Receptor 7 (TLR7) agonist, with potential immunostimulating activity. Upon oral administration, TLR7 agonist APR003 targets, binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity. APR003 is localized in the gastrointestinal (GI) tract and liver, which may promote local immune responses and local tumor eradication and prevent systemic adverse effects." @default.
- NCIT_C178436 NCIT_A7 NCIT_C30108 @default.
- NCIT_C178436 NCIT_NHC0 "C178436" @default.
- NCIT_C178436 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178436 NCIT_P108 "TLR7 Agonist APR003" @default.
- NCIT_C178436 NCIT_P208 "CL1648138" @default.
- NCIT_C178436 NCIT_P322 "GDC" @default.
- NCIT_C178436 NCIT_P329 "804541" @default.
- NCIT_C178436 NCIT_P330 "804541" @default.
- NCIT_C178436 NCIT_P399 "804541" @default.
- NCIT_C178436 normalizedInformationContent "100" @default.
- NCIT_C178436 referenceCount "1" @default.
- NCIT_C178436 hasExactSynonym "APR 003" @default.
- NCIT_C178436 hasExactSynonym "APR-003" @default.
- NCIT_C178436 hasExactSynonym "APR003" @default.
- NCIT_C178436 hasExactSynonym "TLR7 Agonist APR003" @default.
- NCIT_C178436 inSubset NCIT_C128784 @default.
- NCIT_C178436 inSubset NCIT_C157711 @default.
- NCIT_C178436 inSubset NCIT_C157712 @default.
- NCIT_C178436 inSubset NCIT_C176424 @default.
- NCIT_C178436 type Class @default.
- NCIT_C178436 isDefinedBy ncit.owl @default.
- NCIT_C178436 label "TLR7 Agonist APR003" @default.
- NCIT_C178436 subClassOf NCIT_C177174 @default.
- NCIT_C178436 subClassOf NCIT_C177176 @default.
- NCIT_C178436 subClassOf NCIT_C178436 @default.
- NCIT_C178436 subClassOf NCIT_C1908 @default.
- NCIT_C178436 subClassOf NCIT_C1909 @default.
- NCIT_C178436 subClassOf NCIT_C2139 @default.
- NCIT_C178436 subClassOf NCIT_C308 @default.