Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C178440> ?p ?o ?g. }
Showing items 1 to 36 of
36
with 100 items per page.
- NCIT_C178440 IAO_0000115 "An orally bioavailable antagonist of both the immunomodulatory checkpoint molecules adenosine A2A receptor (A2AR; ADORA2A) and A2B receptor (A2BR; ADORA2B), with potential immunomodulating and antineoplastic activities. Upon oral administration, A2A/A2B adenosine receptor antagonist INCB106385 competes with tumor-released adenosine for binding to A2AR and A2BR expressed on numerous intra-tumoral immune cells, such as dendritic cells (DCs), natural killer (NK) cells, macrophages and T-lymphocytes. The binding of INCB106385 to A2AR and A2BR inhibits A2AR/A2BR activity and prevents adenosine-A2AR/A2BR-mediated signaling. A2AR/A2BR inhibition activates and enhances the proliferation of various immune cells, abrogates the adenosine-mediated immunosuppression in the tumor microenvironment (TME) and activates the immune system to exert anti-tumor immune responses against cancer cells, which leads to tumor cell killing. A2AR and A2BR, G protein-coupled signaling receptors, are expressed on the cell surfaces of numerous immune cells. Adenosine is often overproduced by tumor cells and plays a key role in immunosuppression and tumor cell proliferation." @default.
- NCIT_C178440 NCIT_A7 NCIT_C38612 @default.
- NCIT_C178440 NCIT_A7 NCIT_C38614 @default.
- NCIT_C178440 NCIT_NHC0 "C178440" @default.
- NCIT_C178440 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178440 NCIT_P107 "A2A/A2B Adenosine Receptor Antagonist INCB106385" @default.
- NCIT_C178440 NCIT_P108 "A2A/A2B Adenosine Receptor Antagonist INCB106385" @default.
- NCIT_C178440 NCIT_P208 "CL1648142" @default.
- NCIT_C178440 NCIT_P322 "CTRP" @default.
- NCIT_C178440 NCIT_P322 "GDC" @default.
- NCIT_C178440 NCIT_P329 "804549" @default.
- NCIT_C178440 NCIT_P330 "804549" @default.
- NCIT_C178440 NCIT_P399 "804549" @default.
- NCIT_C178440 normalizedInformationContent "100" @default.
- NCIT_C178440 referenceCount "1" @default.
- NCIT_C178440 hasExactSynonym "A2A/A2B Adenosine Receptor Antagonist INCB106385" @default.
- NCIT_C178440 hasExactSynonym "A2AR/A2BR Antagonist INCB106385" @default.
- NCIT_C178440 hasExactSynonym "INCB 106385" @default.
- NCIT_C178440 hasExactSynonym "INCB-106385" @default.
- NCIT_C178440 hasExactSynonym "INCB106385" @default.
- NCIT_C178440 inSubset NCIT_C116977 @default.
- NCIT_C178440 inSubset NCIT_C116978 @default.
- NCIT_C178440 inSubset NCIT_C128784 @default.
- NCIT_C178440 inSubset NCIT_C157711 @default.
- NCIT_C178440 inSubset NCIT_C157712 @default.
- NCIT_C178440 inSubset NCIT_C176424 @default.
- NCIT_C178440 type Class @default.
- NCIT_C178440 isDefinedBy ncit.owl @default.
- NCIT_C178440 label "A2A/A2B Adenosine Receptor Antagonist INCB106385" @default.
- NCIT_C178440 subClassOf NCIT_C178440 @default.
- NCIT_C178440 subClassOf NCIT_C1908 @default.
- NCIT_C178440 subClassOf NCIT_C1909 @default.
- NCIT_C178440 subClassOf NCIT_C201170 @default.
- NCIT_C178440 subClassOf NCIT_C201171 @default.
- NCIT_C178440 subClassOf NCIT_C2139 @default.
- NCIT_C178440 subClassOf NCIT_C308 @default.