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- NCIT_C178446 IAO_0000115 "A tetravalent, bispecific antibody composed of a single-chain variable fragment (scFv) targeting epidermal growth factor receptor (EGFR) fused to the c-terminus of an immunoglobulin G1 (IgG1) antibody targeting hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met bispecific antibody CKD-702 simultaneously targets and binds to the extracellular domains of wild-type or certain mutant forms of both EGFR and c-Met expressed on cancer cells, thereby preventing receptor phosphorylation. This prevents the activation of both EGFR- and c-Met-mediated signaling pathways. In addition, binding results in receptor degradation, which further inhibits EGFR- and c-Met-mediated signaling, thereby inhibiting tumor cell proliferation. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation." @default.
- NCIT_C178446 NCIT_A7 NCIT_C17068 @default.
- NCIT_C178446 NCIT_A7 NCIT_C18186 @default.
- NCIT_C178446 NCIT_NHC0 "C178446" @default.
- NCIT_C178446 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178446 NCIT_P108 "Anti-EGFR/c-Met Bispecific Antibody CKD-702" @default.
- NCIT_C178446 NCIT_P208 "CL1648147" @default.
- NCIT_C178446 NCIT_P322 "GDC" @default.
- NCIT_C178446 NCIT_P329 "804558" @default.
- NCIT_C178446 NCIT_P330 "804558" @default.
- NCIT_C178446 NCIT_P399 "804558" @default.
- NCIT_C178446 normalizedInformationContent "100" @default.
- NCIT_C178446 referenceCount "1" @default.
- NCIT_C178446 hasExactSynonym "Anti-EGFR/Anti-c-Met Bispecific Antibody CKD-702" @default.
- NCIT_C178446 hasExactSynonym "Anti-EGFR/c-Met Bispecific Antibody CKD-702" @default.
- NCIT_C178446 hasExactSynonym "CKD 702" @default.
- NCIT_C178446 hasExactSynonym "CKD-702" @default.
- NCIT_C178446 hasExactSynonym "CKD702" @default.
- NCIT_C178446 hasExactSynonym "EGFR x c-Met Bispecific Antibody CKD-702" @default.
- NCIT_C178446 inSubset NCIT_C128784 @default.
- NCIT_C178446 inSubset NCIT_C157711 @default.
- NCIT_C178446 inSubset NCIT_C157712 @default.
- NCIT_C178446 inSubset NCIT_C176424 @default.
- NCIT_C178446 type Class @default.
- NCIT_C178446 isDefinedBy ncit.owl @default.
- NCIT_C178446 label "Anti-EGFR/c-Met Bispecific Antibody CKD-702" @default.
- NCIT_C178446 subClassOf NCIT_C1454 @default.
- NCIT_C178446 subClassOf NCIT_C178446 @default.
- NCIT_C178446 subClassOf NCIT_C1908 @default.
- NCIT_C178446 subClassOf NCIT_C1909 @default.
- NCIT_C178446 subClassOf NCIT_C307 @default.
- NCIT_C178446 subClassOf NCIT_C308 @default.