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- NCIT_C178449 IAO_0000115 "A bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD1/CTLA4 bispecific antibody SI-B003 targets and binds to both PD-1 and CTLA4 expressed on tumor-infiltrating T lymphocytes (TILs), and inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a sustained cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD1 and CTLA4 with SI-B003 may enhance T-cell activation and proliferation more than the blockade of either immune checkpoint receptor alone." @default.
- NCIT_C178449 NCIT_A7 NCIT_C17489 @default.
- NCIT_C178449 NCIT_A7 NCIT_C94697 @default.
- NCIT_C178449 NCIT_NHC0 "C178449" @default.
- NCIT_C178449 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178449 NCIT_P108 "Anti-PD-1/CTLA-4 Bispecific Antibody SI-B003" @default.
- NCIT_C178449 NCIT_P208 "CL1648120" @default.
- NCIT_C178449 NCIT_P322 "GDC" @default.
- NCIT_C178449 NCIT_P329 "804579" @default.
- NCIT_C178449 NCIT_P330 "804579" @default.
- NCIT_C178449 NCIT_P399 "804579" @default.
- NCIT_C178449 NCIT_R124 NCIT_C17710 @default.
- NCIT_C178449 NCIT_R124 NCIT_C17828 @default.
- NCIT_C178449 NCIT_R124 NCIT_C18219 @default.
- NCIT_C178449 NCIT_R124 NCIT_C19986 @default.
- NCIT_C178449 NCIT_R124 NCIT_C40474 @default.
- NCIT_C178449 normalizedInformationContent "100" @default.
- NCIT_C178449 referenceCount "1" @default.
- NCIT_C178449 hasExactSynonym "Anti-PD-1/Anti-CTLA-4 Bispecific Antibody SI-B003" @default.
- NCIT_C178449 hasExactSynonym "Anti-PD-1/CTLA-4 Bispecific Antibody SI-B003" @default.
- NCIT_C178449 hasExactSynonym "PD-1 x CTLA-4 Bispecific Antibody SI-B003" @default.
- NCIT_C178449 hasExactSynonym "SI B003" @default.
- NCIT_C178449 hasExactSynonym "SI-B003" @default.
- NCIT_C178449 hasExactSynonym "SIB003" @default.
- NCIT_C178449 inSubset NCIT_C128784 @default.
- NCIT_C178449 inSubset NCIT_C157711 @default.
- NCIT_C178449 inSubset NCIT_C157712 @default.
- NCIT_C178449 inSubset NCIT_C176424 @default.
- NCIT_C178449 type Class @default.
- NCIT_C178449 isDefinedBy ncit.owl @default.
- NCIT_C178449 label "Anti-PD-1/CTLA-4 Bispecific Antibody SI-B003" @default.
- NCIT_C178449 subClassOf NCIT_C129821 @default.
- NCIT_C178449 subClassOf NCIT_C129822 @default.
- NCIT_C178449 subClassOf NCIT_C141144 @default.
- NCIT_C178449 subClassOf NCIT_C143250 @default.
- NCIT_C178449 subClassOf NCIT_C1454 @default.
- NCIT_C178449 subClassOf NCIT_C178449 @default.
- NCIT_C178449 subClassOf NCIT_C1908 @default.
- NCIT_C178449 subClassOf NCIT_C1909 @default.
- NCIT_C178449 subClassOf NCIT_C20401 @default.
- NCIT_C178449 subClassOf NCIT_C274 @default.
- NCIT_C178449 subClassOf NCIT_C28227 @default.
- NCIT_C178449 subClassOf NCIT_C307 @default.
- NCIT_C178449 subClassOf NCIT_C308 @default.