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- NCIT_C178567 IAO_0000115 "A protein complex composed of five activated complement proteins that form a transmembrane pore in pathogen cell membranes. Formation of the complex is initiated by C5 convertase cleavage of complement C5 that yields C5b. C5b forms a complex with C6 and then C7; this initial complex has an exposed hydrophobic site that can insert into the pathogen's cell membrane. Then the trimeric C8 is recruited to the complex and the C5b-6-7-8 complex promotes the polymerization of 10-16 molecules of C9, which form the pore. If enough of these pores penetrate the cell membrane of the pathogen, the targeted cell will lyse and die." @default.
- NCIT_C178567 NCIT_NHC0 "C178567" @default.
- NCIT_C178567 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C178567 NCIT_P108 "Membrane Attack Complex" @default.
- NCIT_C178567 NCIT_P207 "C0009545" @default.
- NCIT_C178567 NCIT_R52 NCIT_C17021 @default.
- NCIT_C178567 NCIT_R52 NCIT_C20027 @default.
- NCIT_C178567 NCIT_R52 NCIT_C21523 @default.
- NCIT_C178567 NCIT_R52 NCIT_C26548 @default.
- NCIT_C178567 NCIT_R53 NCIT_C17828 @default.
- NCIT_C178567 NCIT_R53 NCIT_C17930 @default.
- NCIT_C178567 NCIT_R53 NCIT_C17937 @default.
- NCIT_C178567 NCIT_R53 NCIT_C18839 @default.
- NCIT_C178567 NCIT_R53 NCIT_C21124 @default.
- NCIT_C178567 NCIT_R53 NCIT_C21519 @default.
- NCIT_C178567 NCIT_R53 NCIT_C41572 @default.
- NCIT_C178567 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C178567 referenceCount "7" @default.
- NCIT_C178567 hasExactSynonym "C5b-6-7-8-9" @default.
- NCIT_C178567 hasExactSynonym "C5b-9" @default.
- NCIT_C178567 hasExactSynonym "Complement C5b-9 Complex" @default.
- NCIT_C178567 hasExactSynonym "MAC" @default.
- NCIT_C178567 hasExactSynonym "Membrane Attack Complex" @default.
- NCIT_C178567 hasExactSynonym "Membrane-Attack Complex" @default.
- NCIT_C178567 hasExactSynonym "TCC" @default.
- NCIT_C178567 hasExactSynonym "Terminal Complement Complex" @default.
- NCIT_C178567 type Class @default.
- NCIT_C178567 isDefinedBy ncit.owl @default.
- NCIT_C178567 label "Membrane Attack Complex" @default.
- NCIT_C178567 subClassOf B16ef18f7917e47e8a91fb31601cbcd78 @default.
- NCIT_C178567 subClassOf B45d7bb753f47ea0436f78993fd189227 @default.
- NCIT_C178567 subClassOf B4859425818c9f82d8367c9d10c3404da @default.
- NCIT_C178567 subClassOf B6038ffab350c9cb5ae57fd06a6e11d70 @default.
- NCIT_C178567 subClassOf NCIT_C178567 @default.
- NCIT_C178567 subClassOf NCIT_C21176 @default.
- NCIT_C178567 subClassOf NCIT_C26548 @default.