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- NCIT_C178636 IAO_0000115 "A messenger ribonucleic acid (mRNA)-based cancer vaccine that encodes five prostate cancer-selective off-the-shelf shared antigens that are separately complexed with liposomes to form serum-stable RNA lipoplexes (RNA-LPX), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of the W_pro1 cancer vaccine, the RNA-LPX are taken up by antigen-presenting cells (APCs), especially dendritic cells (DCs). Upon uptake, the antigens are translated, processed, and presented to the immune system on major histocompatibility complex (MHC) class I and II molecules. This may activate the immune system to induce both an adaptive and innate immune response against cancer cells expressing these five antigens." @default.
- NCIT_C178636 NCIT_NHC0 "C178636" @default.
- NCIT_C178636 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C178636 NCIT_P107 "W_pro1 Cancer Vaccine" @default.
- NCIT_C178636 NCIT_P108 "W_pro1 Cancer Vaccine" @default.
- NCIT_C178636 NCIT_P208 "CL1648300" @default.
- NCIT_C178636 NCIT_P322 "CTRP" @default.
- NCIT_C178636 NCIT_P322 "GDC" @default.
- NCIT_C178636 NCIT_P399 "805699" @default.
- NCIT_C178636 normalizedInformationContent "100" @default.
- NCIT_C178636 referenceCount "1" @default.
- NCIT_C178636 hasExactSynonym "BNT 112" @default.
- NCIT_C178636 hasExactSynonym "BNT-112" @default.
- NCIT_C178636 hasExactSynonym "BNT112" @default.
- NCIT_C178636 hasExactSynonym "RNA-LPX BNT112" @default.
- NCIT_C178636 hasExactSynonym "RNA-lipoplex Cancer Vaccine BNT112" @default.
- NCIT_C178636 hasExactSynonym "RNA-lipoplex Vaccine BNT112" @default.
- NCIT_C178636 hasExactSynonym "W pro1" @default.
- NCIT_C178636 hasExactSynonym "WP1 Cancer Vaccine" @default.
- NCIT_C178636 hasExactSynonym "W_pro1 Cancer Vaccine" @default.
- NCIT_C178636 hasExactSynonym "W_pro1" @default.
- NCIT_C178636 hasExactSynonym "Wpro1" @default.
- NCIT_C178636 inSubset NCIT_C116977 @default.
- NCIT_C178636 inSubset NCIT_C116978 @default.
- NCIT_C178636 inSubset NCIT_C128784 @default.
- NCIT_C178636 inSubset NCIT_C157711 @default.
- NCIT_C178636 inSubset NCIT_C157712 @default.
- NCIT_C178636 inSubset NCIT_C176424 @default.
- NCIT_C178636 type Class @default.
- NCIT_C178636 isDefinedBy ncit.owl @default.
- NCIT_C178636 label "W_pro1 Cancer Vaccine" @default.
- NCIT_C178636 subClassOf NCIT_C129820 @default.
- NCIT_C178636 subClassOf NCIT_C1663 @default.
- NCIT_C178636 subClassOf NCIT_C172787 @default.
- NCIT_C178636 subClassOf NCIT_C178636 @default.
- NCIT_C178636 subClassOf NCIT_C181141 @default.
- NCIT_C178636 subClassOf NCIT_C1908 @default.
- NCIT_C178636 subClassOf NCIT_C1909 @default.
- NCIT_C178636 subClassOf NCIT_C274 @default.
- NCIT_C178636 subClassOf NCIT_C307 @default.
- NCIT_C178636 subClassOf NCIT_C308 @default.
- NCIT_C178636 subClassOf NCIT_C923 @default.