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- NCIT_C17891 IAO_0000115 "Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions. NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis. Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation. NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding. The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation. Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications. (from OMIM 116930 and NCI)" @default.
- NCIT_C17891 NCIT_NHC0 "C17891" @default.
- NCIT_C17891 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C17891 NCIT_P106 "Neuroreactive Substance or Biogenic Amine" @default.
- NCIT_C17891 NCIT_P108 "CD56 Antigen" @default.
- NCIT_C17891 NCIT_P200 "Cell Adhesion Molecule" @default.
- NCIT_C17891 NCIT_P203 "Protein_Kind" @default.
- NCIT_C17891 NCIT_P204 "Protein_Encoded_by_Gene|NCAM1 Gene" @default.
- NCIT_C17891 NCIT_P204 "Protein_Expressed_In_Tissue|Natural Killer Cell" @default.
- NCIT_C17891 NCIT_P204 "Protein_Expressed_In_Tissue|T Cell" @default.
- NCIT_C17891 NCIT_P204 "Protein_Has_Biochemical_Function|Glycoprotein" @default.
- NCIT_C17891 NCIT_P204 "Protein_Has_Biochemical_Function|Transmembrane Protein" @default.
- NCIT_C17891 NCIT_P310 "Retired_Concept" @default.
- NCIT_C17891 NCIT_P325 "Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56 (ANTIGENS, CD56), but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)" @default.
- NCIT_C17891 NCIT_P325 "immunoglobulin-like neuronal surface glycoprotein which binds to a variety of other cell adhesion proteins to mediate adhesion, guidance, and differentiation during neuronal growth; may contain covalent phospholipid." @default.
- NCIT_C17891 NCIT_P98 "Use 'Neural Cell Adhesion Molecule'" @default.
- NCIT_C17891 normalizedInformationContent "100" @default.
- NCIT_C17891 referenceCount "1" @default.
- NCIT_C17891 hasExactSynonym "CD56 Antigen" @default.
- NCIT_C17891 hasExactSynonym "CD56" @default.
- NCIT_C17891 hasExactSynonym "NCAM" @default.
- NCIT_C17891 hasExactSynonym "NKH-1" @default.
- NCIT_C17891 hasExactSynonym "Neural Cell Adhesion Molecule" @default.
- NCIT_C17891 type Class @default.
- NCIT_C17891 isDefinedBy ncit.owl @default.
- NCIT_C17891 label "CD56 Antigen" @default.
- NCIT_C17891 subClassOf NCIT_C17891 @default.
- NCIT_C17891 subClassOf NCIT_C28428 @default.
- NCIT_C17891 subClassOf NCIT_C83479 @default.
- NCIT_C17891 deprecated "true" @default.