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- NCIT_C179080 IAO_0000115 "A small-molecule inhibitor of the serine-threonine kinase Aurora B, with potential antineoplastic activity. Upon administration, defosbarasertib specifically binds to and inhibits Aurora kinase B, which disrupts spindle checkpoint functions and chromosome alignment, and results in the disruption of chromosome segregation and cytokinesis. This inhibits cell division and cell proliferation and induces apoptosis in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types." @default.
- NCIT_C179080 NCIT_A7 NCIT_C68596 @default.
- NCIT_C179080 NCIT_NHC0 "C179080" @default.
- NCIT_C179080 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C179080 NCIT_P107 "Defosbarasertib" @default.
- NCIT_C179080 NCIT_P108 "Defosbarasertib" @default.
- NCIT_C179080 NCIT_P208 "CL1648420" @default.
- NCIT_C179080 NCIT_P210 "722544-51-6" @default.
- NCIT_C179080 NCIT_P319 "29P8LWS24N" @default.
- NCIT_C179080 NCIT_P322 "CTRP" @default.
- NCIT_C179080 NCIT_P322 "FDA" @default.
- NCIT_C179080 NCIT_P322 "GDC" @default.
- NCIT_C179080 NCIT_P399 "806250" @default.
- NCIT_C179080 NCIT_R146 NCIT_C16554 @default.
- NCIT_C179080 NCIT_R146 NCIT_C16984 @default.
- NCIT_C179080 NCIT_R146 NCIT_C17018 @default.
- NCIT_C179080 NCIT_R146 NCIT_C17021 @default.
- NCIT_C179080 NCIT_R146 NCIT_C17210 @default.
- NCIT_C179080 NCIT_R146 NCIT_C17325 @default.
- NCIT_C179080 NCIT_R146 NCIT_C20027 @default.
- NCIT_C179080 NCIT_R146 NCIT_C26548 @default.
- NCIT_C179080 NCIT_R146 NCIT_C30006 @default.
- NCIT_C179080 normalizedInformationContent "100" @default.
- NCIT_C179080 referenceCount "1" @default.
- NCIT_C179080 hasExactSynonym "AZD 2811" @default.
- NCIT_C179080 hasExactSynonym "AZD-2811" @default.
- NCIT_C179080 hasExactSynonym "AZD1152-hQPA" @default.
- NCIT_C179080 hasExactSynonym "AZD2811" @default.
- NCIT_C179080 hasExactSynonym "DEFOSBARASERTIB" @default.
- NCIT_C179080 hasExactSynonym "Defosbarasertib" @default.
- NCIT_C179080 inSubset NCIT_C116977 @default.
- NCIT_C179080 inSubset NCIT_C116978 @default.
- NCIT_C179080 inSubset NCIT_C128784 @default.
- NCIT_C179080 inSubset NCIT_C157711 @default.
- NCIT_C179080 inSubset NCIT_C157712 @default.
- NCIT_C179080 inSubset NCIT_C176424 @default.
- NCIT_C179080 inSubset NCIT_C63923 @default.
- NCIT_C179080 type Class @default.
- NCIT_C179080 isDefinedBy ncit.owl @default.
- NCIT_C179080 label "Defosbarasertib" @default.
- NCIT_C179080 subClassOf NCIT_C129824 @default.
- NCIT_C179080 subClassOf NCIT_C129825 @default.
- NCIT_C179080 subClassOf NCIT_C1404 @default.
- NCIT_C179080 subClassOf NCIT_C179080 @default.
- NCIT_C179080 subClassOf NCIT_C1908 @default.
- NCIT_C179080 subClassOf NCIT_C1909 @default.
- NCIT_C179080 subClassOf NCIT_C2189 @default.
- NCIT_C179080 subClassOf NCIT_C274 @default.
- NCIT_C179080 subClassOf NCIT_C471 @default.
- NCIT_C179080 subClassOf NCIT_C61074 @default.
- NCIT_C179080 subClassOf NCIT_C62556 @default.